Affordability Check
How to afford AUVELITY
Generic name: dextromethorphan hydrobromide, bupropion hydrochloride
Pick how you're covered. We'll show you the cheapest legitimate way to get AUVELITY — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About AUVELITY and its cost
What is this medication? Auvelity is a prescription medication used to treat major depressive disorder in adults. It is a combination drug that contains two active ingredients: dextromethorphan hydrobromide and bupropion hydrochloride. One of the primary features that distinguishes this treatment from many older antidepressants is its rapid onset of action, as it is designed to help improve depressive symptoms in as little as one week.
The medication works by utilizing a unique mechanism that targets neurotransmitter pathways in the brain differently than standard selective serotonin reuptake inhibitors. Dextromethorphan acts as an NMDA receptor antagonist to help regulate mood, while bupropion serves as an antidepressant and a booster that increases the levels of dextromethorphan in the body. Together, these components work to balance brain chemistry and alleviate the persistent feelings of sadness and loss of interest associated with clinical depression.
AUVELITY is made by Axsome. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford AUVELITY?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for AUVELITY?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Axsome has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover AUVELITY?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for Major Depressive Disorder?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about AUVELITY
Full AUVELITY drug page
FDA label, prior authorization rules, full indications list
More options for Major Depressive Disorder
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3