Is this a complete drug-interaction database?

No. We query the FDA-approved labels (via openFDA) for each drug and look for mentions of the other drugs you selected. FDA labels cover the most clinically significant interactions — but not every possible one. A pharmacist has access to comprehensive databases (First Databank, Multum, Lexicomp) that we don't. Treat this tool as a "what do the official labels explicitly say" check, not a full clinical review.

What happens when a drug has no available FDA label?

Older generics and some compounded products don't always return a label from openFDA. We show an amber warning listing which drugs couldn't be checked, and the interaction results are based only on the drugs where labels were found. If a critical drug is missing, ask your pharmacist to run a formal check.

Does this check over-the-counter drugs, supplements, or foods?

No. This tool is scoped to FDA-approved prescription drugs in our catalog. Grapefruit, St. John's Wort, iron supplements, alcohol, and similar interactions aren't covered here — that's pharmacist territory.

Where does the interaction text come from?

Every excerpt comes from the FDA-approved Structured Product Label (SPL) for that specific drug, pulled live from openFDA (https://open.fda.gov/apis/drug/label/). We don't paraphrase. Each card links back to the drug page on RxCopays, which can link out to the DailyMed SPL source.

What should I do if I find an interaction flagged here?

Don't stop any medication on your own. Bring the results to your prescribing clinician or pharmacist. Many label-flagged interactions are manageable with dose adjustment or timing changes — but that's a clinical decision, not a DIY one.

Safety tool

Drug interaction checker

Check whether two or more of your prescription drugs are flagged for interactions on their FDA-approved labels. Primary-source data only — no hallucinations, no guesses.

Read before using:

This is not a complete interaction database. Your pharmacist has access to more.
Don't change any medication based on this tool alone.
Over-the-counter drugs, supplements, and food aren't covered.

Add at least 2 drugs to check.

Frequently asked

Is this a complete drug-interaction database?: No. We query the FDA-approved labels (via openFDA) for each drug and look for mentions of the other drugs you selected. FDA labels cover the most clinically significant interactions — but not every possible one. A pharmacist has access to comprehensive databases (First Databank, Multum, Lexicomp) that we don't. Treat this tool as a "what do the official labels explicitly say" check, not a full clinical review.
What happens when a drug has no available FDA label?: Older generics and some compounded products don't always return a label from openFDA. We show an amber warning listing which drugs couldn't be checked, and the interaction results are based only on the drugs where labels were found. If a critical drug is missing, ask your pharmacist to run a formal check.
Does this check over-the-counter drugs, supplements, or foods?: No. This tool is scoped to FDA-approved prescription drugs in our catalog. Grapefruit, St. John's Wort, iron supplements, alcohol, and similar interactions aren't covered here — that's pharmacist territory.
Where does the interaction text come from?: Every excerpt comes from the FDA-approved Structured Product Label (SPL) for that specific drug, pulled live from openFDA (https://open.fda.gov/apis/drug/label/). We don't paraphrase. Each card links back to the drug page on RxCopays, which can link out to the DailyMed SPL source.
What should I do if I find an interaction flagged here?: Don't stop any medication on your own. Bring the results to your prescribing clinician or pharmacist. Many label-flagged interactions are manageable with dose adjustment or timing changes — but that's a clinical decision, not a DIY one.

How this works technically:When you check, we look up each drug's FDA-approved Structured Product Label (SPL) via the openFDA /drug/label endpoint (open.fda.gov/apis/drug/label), extract the drug_interactionssection, and search for mentions of the other drugs' brand names, generic names, and active ingredients. Only FDA-authored text is shown — we don't paraphrase.

See our accuracy policy for how we source and verify data.