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Affordability Check

How to afford CRYSVITA

Generic name: Burosumab

Pick how you're covered. We'll show you the cheapest legitimate way to get CRYSVITA — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.

How are you covered for prescriptions?

Pick the one that fits you. We'll show you the cheapest way to get this drug.

Pick an option above to see your specific path.

Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.

About CRYSVITA and its cost

What is this medication? CRYSVITA is a prescription medicine used to treat adults and children six months of age and older with X-linked hypophosphatemia, often referred to as XLH. It is also approved for the treatment of FGF23-related tumor-induced osteomalacia, or TIO, in patients two years of age and older when the tumor cannot be located or removed. This medication is a biological therapy known as a fibroblast growth factor 23 blocking antibody, which helps address the root cause of these specific metabolic bone diseases.

The medication works by targeting and inhibiting a protein called FGF23, which is responsible for flushing phosphorus out of the body through the kidneys. In patients with XLH or TIO, excess levels of this protein cause phosphorus levels to drop too low, leading to weakened bones, pain, and dental issues. By blocking this protein, CRYSVITA allows the kidneys to reabsorb phosphorus into the bloodstream, thereby improving bone mineralization and helping to relieve symptoms associated with these conditions.

CRYSVITA is made by Ultragenyx. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.

Common questions

What's the cheapest way to afford CRYSVITA?

It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.

Can I use a copay card with Medicare for CRYSVITA?

No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Ultragenyx has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.

Does my Medicare Part D plan cover CRYSVITA?

Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.

How long does a Patient Assistance Program take?

Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.

What if I have a high-deductible plan?

For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.

Are there charity grants for Familial Hypophosphatemia?

Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.

More about CRYSVITA