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Affordability Check

How to afford DEFITELIO

Generic name: defibrotide sodium

Pick how you're covered. We'll show you the cheapest legitimate way to get DEFITELIO — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.

How are you covered for prescriptions?

Pick the one that fits you. We'll show you the cheapest way to get this drug.

Pick an option above to see your specific path.

Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.

About DEFITELIO and its cost

What is this medication? Defitelio is a prescription intravenous medication used to treat adults and children who develop hepatic veno-occlusive disease, also known as sinusoidal obstruction syndrome, following a hematopoietic stem-cell transplant. This condition occurs when the small blood vessels in the liver become blocked, leading to serious liver damage and restricted blood flow. The medication is specifically prescribed for patients who experience these liver complications along with additional signs of kidney or lung dysfunction after their transplant.

The medication functions as an antithrombotic and fibrinolytic agent, which means it helps prevent and break down blood clots while protecting the lining of the blood vessels. By reducing procoagulant activity and increasing the breakdown of clots, it helps restore normal circulation within the liver and supports organ recovery. It is administered by a healthcare provider in a medical setting, as patients must be monitored for potential complications such as hemorrhage or hypersensitivity reactions.

DEFITELIO is made by Jazz. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.

Common questions

What's the cheapest way to afford DEFITELIO?

It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.

Can I use a copay card with Medicare for DEFITELIO?

No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Jazz has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.

Does my Medicare Part D plan cover DEFITELIO?

Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.

How long does a Patient Assistance Program take?

Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.

What if I have a high-deductible plan?

For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.

Are there charity grants for Liver Disease?

Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.

More about DEFITELIO