Affordability Check
How to afford Endari
Generic name: Glutamine
Pick how you're covered. We'll show you the cheapest legitimate way to get Endari — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About Endari and its cost
What is this medication? Endari is a prescription medication, also known as L-glutamine oral powder, that is used to reduce the acute complications of sickle cell disease. It is indicated for use in adult and pediatric patients who are five years of age or older. The treatment is designed to lower the frequency of pain crises and other severe symptoms that often lead to emergency room visits or hospitalizations for people living with this genetic blood condition.
This medication works by providing red blood cells with the necessary components to combat oxidative stress. Sickle red blood cells are particularly vulnerable to damage from oxidation, which causes them to become stiff and sticky. By increasing the availability of glutamine, the medicine helps the cells produce antioxidants that maintain their flexibility and health. This process makes the cells less likely to cause blockages in the blood vessels, thereby reducing the overall burden of the disease.
Endari is made by Emmaus. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford Endari?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for Endari?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Emmaus has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover Endari?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for Sickle Cell Disease?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about Endari
Full Endari drug page
FDA label, prior authorization rules, full indications list
More options for Sickle Cell Disease
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3