Affordability Check
How to afford Krystexxa
Generic name: pegloticase
Pick how you're covered. We'll show you the cheapest legitimate way to get Krystexxa — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About Krystexxa and its cost
What is this medication? Krystexxa is a prescription medication used to treat adults with chronic gout that has not responded to conventional oral treatments. This condition, often referred to as refractory gout, occurs when standard medications fail to sufficiently lower uric acid levels in the blood. By lowering these levels, the medication helps to reduce the painful crystals that build up in the joints and soft tissues of people suffering from this long-term condition.
The drug works as an enzyme that converts uric acid into allantoin, a water-soluble substance that the body can easily clear through urination. Unlike many other gout treatments that are taken as daily pills, this medication is administered by a healthcare professional through an intravenous infusion every two weeks. It is typically reserved for patients who continue to experience frequent gout flares or have developed visible deposits of uric acid crystals known as tophi.
Krystexxa is made by Amgen. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford Krystexxa?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for Krystexxa?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Amgen has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover Krystexxa?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for Gout?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about Krystexxa
Full Krystexxa drug page
FDA label, prior authorization rules, full indications list
More options for Gout
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3