Affordability Check
How to afford Lumizyme
Generic name: ALGLUCOSIDASE ALFA
Pick how you're covered. We'll show you the cheapest legitimate way to get Lumizyme — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About Lumizyme and its cost
What is this medication? Lumizyme is a prescription medication used for the treatment of Pompe disease, a rare genetic condition also referred to as acid alpha-glucosidase deficiency. In patients with this disorder, the body fails to produce enough of a specific enzyme that is essential for breaking down a complex sugar called glycogen. This deficiency causes glycogen to accumulate to toxic levels in the cells, primarily affecting the heart and various muscle groups throughout the body, which leads to progressive muscle weakness and breathing difficulties.
This medication functions as an enzyme replacement therapy by delivering alglucosidase alfa, which acts as a substitute for the natural enzyme the body is missing. By replacing the deficient enzyme, the treatment helps clear excess glycogen from the cells and can help manage symptoms or slow the decline of muscle and respiratory health. It is given as an intravenous infusion by medical professionals and is indicated for use in both pediatric and adult populations.
Lumizyme is made by Sanofi. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford Lumizyme?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for Lumizyme?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Sanofi has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover Lumizyme?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for Pompe disease?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about Lumizyme
Full Lumizyme drug page
FDA label, prior authorization rules, full indications list
More options for Pompe disease
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3