Affordability Check
How to afford ODEFSEY
Generic name: emtricitabine, rilpivirine hydrochloride, and tenofovir alafenamide
Pick how you're covered. We'll show you the cheapest legitimate way to get ODEFSEY — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About ODEFSEY and its cost
What is this medication? Odefsey is a prescription medication used as a complete regimen to treat HIV-1 infection in adults and pediatric patients weighing at least thirty-five kilograms. It is specifically indicated for patients who have never undergone antiretroviral therapy or as a replacement for a stable regimen in those who are virologically suppressed. While it helps to lower the viral load and improve immune function, it is not a cure for HIV or AIDS and must be taken consistently as directed by a healthcare provider.
The tablet contains a combination of three antiretroviral drugs: emtricitabine, rilpivirine, and tenofovir alafenamide. These ingredients work together to inhibit the enzymes the virus uses to replicate itself, thereby preventing the virus from spreading further in the body. For the medication to be fully effective and properly absorbed, it should be taken once daily with a full meal.
ODEFSEY is made by Gilead Sciences. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford ODEFSEY?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for ODEFSEY?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Gilead Sciences has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover ODEFSEY?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for HIV-1 Infection?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about ODEFSEY
Full ODEFSEY drug page
FDA label, prior authorization rules, full indications list
More options for HIV-1 Infection
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3