Affordability Check
How to afford OPVEE
Generic name: nalmefene hydrochloride
Pick how you're covered. We'll show you the cheapest legitimate way to get OPVEE — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About OPVEE and its cost
What is this medication? OPVEE is a prescription nasal spray containing nalmefene that is used for the emergency treatment of a known or suspected opioid overdose. It is designed to be used in adults and pediatric patients who are at least 12 years of age. This medication is intended to quickly reverse the life-threatening effects of opioids, including synthetic substances like fentanyl, when a person experiences severe respiratory depression or becomes unresponsive.
The medication works as an opioid antagonist, meaning it binds to opioid receptors in the brain to block the effects of the drugs. While OPVEE can provide immediate assistance during a medical emergency, it is not a substitute for professional medical care. After the dose is administered, it is essential to call for emergency medical help right away, as the person may require further observation or additional treatment to ensure their safety.
OPVEE is made by Indivior. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford OPVEE?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for OPVEE?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Indivior has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover OPVEE?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for Opioid Overdose?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about OPVEE
Full OPVEE drug page
FDA label, prior authorization rules, full indications list
More options for Opioid Overdose
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3