Affordability Check
How to afford PIQRAY
Generic name: alpelisib
Pick how you're covered. We'll show you the cheapest legitimate way to get PIQRAY — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About PIQRAY and its cost
What is this medication? Piqray is a prescription medication used in combination with fulvestrant for the treatment of certain adults with hormone receptor-positive, human epidermal growth factor receptor 2-negative, advanced or metastatic breast cancer. This treatment is specifically for patients whose cancer has a PIK3CA mutation as detected by an FDA-approved test and has progressed following an endocrine-based regimen. It belongs to a class of drugs known as kinase inhibitors and is used for postmenopausal women and men.
The medication works by blocking a specific protein called PI3K, which helps regulate cell growth. In cancers with a PIK3CA mutation, this protein becomes overactive, allowing cancer cells to multiply and survive. By inhibiting this protein, the drug helps slow the progression of the disease. Patients taking this medication require regular monitoring by their doctor, as it can lead to side effects such as high blood sugar levels, rash, or kidney problems.
PIQRAY is made by a pharmaceutical manufacturer. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford PIQRAY?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for PIQRAY?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But the manufacturer has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover PIQRAY?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for Cancer?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about PIQRAY
Full PIQRAY drug page
FDA label, prior authorization rules, full indications list
More options for Cancer
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3