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Affordability Check

How to afford SYMDEKO

Generic name: Tezacaftor and Ivacaftor

Pick how you're covered. We'll show you the cheapest legitimate way to get SYMDEKO — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.

How are you covered for prescriptions?

Pick the one that fits you. We'll show you the cheapest way to get this drug.

Pick an option above to see your specific path.

Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.

About SYMDEKO and its cost

What is this medication? SYMDEKO is a prescription medicine used for the treatment of cystic fibrosis in adults and pediatric patients aged 6 years and older. It is a combination therapy that contains two active ingredients, tezacaftor and ivacaftor, which are classified as CFTR modulators. This medication is specifically indicated for patients who have two copies of the F508del mutation in their CFTR gene or who have at least one mutation in the CFTR gene that is responsive to the medicine based on clinical or laboratory data.

The drug works by helping the CFTR protein function more effectively at the cell surface, which facilitates the proper movement of salt and water into and out of the lungs and other organs. By improving this cellular process, the medication helps to thin the thick, sticky mucus associated with cystic fibrosis, thereby improving lung function and overall respiratory health. Because it targets specific genetic profiles, a healthcare provider must perform a genetic test to ensure the patient has the compatible mutations before prescribing the treatment.

SYMDEKO is made by Vertex. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.

Common questions

What's the cheapest way to afford SYMDEKO?

It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.

Can I use a copay card with Medicare for SYMDEKO?

No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Vertex has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.

Does my Medicare Part D plan cover SYMDEKO?

Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.

How long does a Patient Assistance Program take?

Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.

What if I have a high-deductible plan?

For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.

Are there charity grants for Cystic Fibrosis?

Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.

More about SYMDEKO