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Affordability Check

How to afford TYSABRI

Generic name: natalizumab

Pick how you're covered. We'll show you the cheapest legitimate way to get TYSABRI — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.

How are you covered for prescriptions?

Pick the one that fits you. We'll show you the cheapest way to get this drug.

Pick an option above to see your specific path.

Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.

About TYSABRI and its cost

What is this medication? Tysabri is a prescription intravenous infusion medication primarily used to treat adults with relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It is designed to help reduce the frequency of clinical relapses and slow the progression of physical disability associated with the condition. By targeting specific proteins in the immune system, the medication helps prevent inflammatory cells from entering the central nervous system where they can cause damage.

In addition to its use for multiple sclerosis, Tysabri is also indicated for the treatment of moderate-to-severe Crohn's disease in adults who have not had an adequate response to, or are unable to tolerate, conventional treatments and other specific medicines. The drug works by blocking the movement of potentially harmful immune cells into the brain, spinal cord, or digestive tract to limit inflammation. Because of the risks associated with the treatment, such as a rare brain infection called progressive multifocal leukoencephalopathy, it is only available through a restricted prescribing and distribution program.

TYSABRI is made by Biogen. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.

Common questions

What's the cheapest way to afford TYSABRI?

It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.

Can I use a copay card with Medicare for TYSABRI?

No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Biogen has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.

Does my Medicare Part D plan cover TYSABRI?

Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.

How long does a Patient Assistance Program take?

Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.

What if I have a high-deductible plan?

For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.

Are there charity grants for Multiple Sclerosis?

Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.

More about TYSABRI