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Affordability Check

How to afford XPOVIO

Generic name: selinexor

Pick how you're covered. We'll show you the cheapest legitimate way to get XPOVIO — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.

How are you covered for prescriptions?

Pick the one that fits you. We'll show you the cheapest way to get this drug.

Pick an option above to see your specific path.

Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.

About XPOVIO and its cost

What is this medication? Xpovio, known generically as selinexor, is a prescription medication primarily used to treat adults with certain types of advanced blood cancers. It is frequently prescribed for patients with multiple myeloma that has returned or did not respond to previous treatments, often used in combination with other drugs such as dexamethasone or bortezomib. Additionally, it is indicated for adults with specific types of diffuse large B-cell lymphoma who have already undergone at least two other types of systemic therapy.

This medication belongs to a class of drugs called selective inhibitors of nuclear export. It works by blocking a protein called XPO1, which normally carries tumor-suppressor proteins out of the cell nucleus. By keeping these protective proteins inside the nucleus, Xpovio helps the body identify and destroy cancer cells while slowing their growth. It is administered as an oral tablet and must be taken exactly as directed by a healthcare professional due to its specific dosing schedules.

XPOVIO is made by Karyopharm. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.

Common questions

What's the cheapest way to afford XPOVIO?

It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.

Can I use a copay card with Medicare for XPOVIO?

No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Karyopharm has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.

Does my Medicare Part D plan cover XPOVIO?

Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.

How long does a Patient Assistance Program take?

Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.

What if I have a high-deductible plan?

For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.

Are there charity grants for Lymphoma?

Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.

More about XPOVIO