Affordability Check
How to afford YONDELIS
Generic name: Trabectedin
Pick how you're covered. We'll show you the cheapest legitimate way to get YONDELIS — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About YONDELIS and its cost
What is this medication? Yondelis, also known by its generic name trabectedin, is a chemotherapy medication used to treat specific types of soft tissue sarcoma. It is primarily indicated for patients with liposarcoma or leiomyosarcoma that is unresectable, meaning it cannot be removed by surgery, or has become metastatic and spread to other parts of the body. This drug belongs to a class of medications called alkylating agents and works by interfering with the genetic material of cancer cells to prevent them from growing and multiplying.
This medication is specifically intended for adult patients who have previously received treatment with an anthracycline-containing chemotherapy regimen. It is administered as an intravenous infusion by a healthcare professional, typically every three weeks. Because it is a specialized treatment for advanced cancers, it is closely monitored by oncology experts to manage its effectiveness and potential side effects during the course of therapy.
YONDELIS is made by Janssen. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford YONDELIS?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for YONDELIS?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Janssen has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover YONDELIS?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for Soft Tissue Sarcoma?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about YONDELIS
Full YONDELIS drug page
FDA label, prior authorization rules, full indications list
More options for Soft Tissue Sarcoma
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3