Affordability Check
How to afford ZIIHERA
Generic name: zanidatamab-hrii
Pick how you're covered. We'll show you the cheapest legitimate way to get ZIIHERA — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About ZIIHERA and its cost
What is this medication? ZIIHERA, which has the generic name zanidatamab-hrii, is a prescription medicine used to treat adults with advanced biliary tract cancer, including gallbladder cancer and bile duct cancer. This medication is specifically indicated for patients whose tumors are HER2-positive and are either unresectable or have spread to other parts of the body. It is typically prescribed for individuals who have already received at least one prior systemic therapy for their cancer.
As a HER2-directed bispecific antibody, this medication works by binding to two different sites on the HER2 proteins located on the surface of cancer cells. By attaching to these specific receptors, the drug helps to block the signals that cause the cancer cells to grow and multiply. Additionally, this targeted action can help the body's own immune system identify and attack the tumor cells to help manage the progression of the disease.
ZIIHERA is made by Jazz. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford ZIIHERA?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for ZIIHERA?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But Jazz has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover ZIIHERA?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for Biliary Tract Cancer?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about ZIIHERA
Full ZIIHERA drug page
FDA label, prior authorization rules, full indications list
More options for Biliary Tract Cancer
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3