Affordability Check
How to afford ZYFLO
Generic name: zileuton
Pick how you're covered. We'll show you the cheapest legitimate way to get ZYFLO — your insurance copay, manufacturer savings, charity grants, or cash price. It takes 30 seconds and we never ask for your personal information.
Pick an option above to see your specific path.
Different insurance means different laws and different savings. For example, Medicare patients cannot use manufacturer copay cards (federal law) — but the manufacturer almost always has a Patient Assistance Program that gives the drug free.
About ZYFLO and its cost
What is this medication? ZYFLO is a prescription medicine used for the long-term prevention and chronic treatment of asthma in adults and children twelve years of age and older. It belongs to a group of drugs called leukotriene synthesis inhibitors, which function by blocking the enzyme responsible for creating inflammatory chemicals in the body. By preventing the production of these substances, the medication helps to reduce the swelling and narrowing of the airways, which assists in managing asthma symptoms more effectively over time.
This medication is designed for daily use and is not meant to be used as a rescue treatment for sudden breathing problems or acute asthma attacks. Because it can affect the liver, healthcare providers typically perform blood tests to monitor liver function before and during treatment. To achieve the best results, patients must take the medication consistently as directed by their physician, even if they are not currently experiencing any symptoms of asthma.
ZYFLO is made by a pharmaceutical manufacturer. Like most brand-name drugs, it's priced at a high list price — but patients rarely pay that list price. The options above are the real paths most people use to get it affordably.
Common questions
What's the cheapest way to afford ZYFLO?
It depends on your insurance. On Medicare, apply for the manufacturer's Patient Assistance Program (PAP) — it gives the drug free if you meet income requirements. With private insurance, the manufacturer copay card usually drops your copay to $0-$25. Uninsured patients should compare the PAP with Cost Plus Drugs cash price.
Can I use a copay card with Medicare for ZYFLO?
No — federal law (the Anti-Kickback Statute) prohibits manufacturer copay cards on Medicare, Medicaid, TriCare, and VA prescriptions. But the manufacturer has a separate Patient Assistance Program for Medicare beneficiaries. Check the options above.
Does my Medicare Part D plan cover ZYFLO?
Part D coverage varies by plan. We query the CMS Prescription Drug Plan file to show you what percentage of plans cover it and at what tier. For your exact copay, pick "Medicare" above and check your plan's Summary of Benefits, or log in to Medicare.gov.
How long does a Patient Assistance Program take?
Most PAPs take 2-6 weeks from application to first fill. Ask the manufacturer about a "bridge supply" — many will ship 30 days free while your application is being reviewed so you don't go without the drug.
What if I have a high-deductible plan?
For generics, Cost Plus Drugs cash price is often cheaper than your deductible-phase copay. For brand names, the manufacturer copay card almost always wins. A GoodRx coupon can be a last resort for uncovered drugs, but it doesn't count toward your deductible.
Are there charity grants for Asthma?
Charities like HealthWell Foundation, PAN Foundation, Good Days, and the National Organization for Rare Disorders provide copay help for specific conditions. Funds often run out mid-year — apply early. We list the specific grants for your condition in the options above.
More about ZYFLO
Full ZYFLO drug page
FDA label, prior authorization rules, full indications list
More options for Asthma
Drugs, grants, and assistance for this condition
Guide to Patient Assistance Programs
How PAPs work, who qualifies, typical wait times
If your insurance denied coverage
5-level appeal playbook — Medicare has a 60% win rate at Level 3