Directory
Conditions
1,213 conditions. Each page links to drugs that treat it, grants available for patients, and — where it's a rare disease — our sister UniteRare page.
- Chronic Post-traumatic PainNeurological
- Chronic Respiratory FailureRespiratory
- Chronic RhinitisRespiratory
- Chronic SinusitisRespiratory
- Chronic Skin UlcerDermatology
- Chronic Spontaneous UrticariaDermatology
- Chronic Sun DamageDermatology
- Chronic Systolic Heart FailureCardiovascular
- Chronic Venous InsufficiencyCardiovascular
- Clostridium Difficile InfectionInfectious Disease
- Cold SoresInfectious Disease
- Colon CancerCancer
- Colon Cancer ScreeningCancer
- Colorectal CancerCancer
- Combined ImmunodeficiencyOther
- Common ColdInfectious Disease
- Complement DeficiencyBlood Disorders
- Complement Deficiency gardenBlood Disorders
- Complete Heart BlockCardiovascular
- Complicated intra-abdominal infections (cIAI)Infectious Disease
- complicated urinary tract infections (cUTI)Infectious Disease
- Complications After Cataract SurgeryOphthalmology
- Complications of cataract surgeryOphthalmology
- Condition Not ListedOther
- Congenital Liver MalformationGastrointestinal
- Congenital Malformation SyndromeGenetic DisorderRare
- Congenital NeutropeniaBlood DisordersRare
- ConjunctivitisOphthalmology
- Conn's SyndromeEndocrine
- ConstipationGastrointestinal
- ContraceptionReproductive Health
- Contraceptive CounselingReproductive Health
- Contraceptive Implant Follow-upReproductive Health
- Contraceptive ManagementOther
- Contraceptive Pill ManagementOther
- COPDRespiratory
- Copper DeficiencyMetabolic
- Cor PulmonaleCardiovascular
- Corneal AbrasionOphthalmology
- Corneal NeovascularizationOphthalmology
- Corneal UlcerOphthalmology
- Coronary Artery DiseaseCardiovascular
- Coronary Artery Disease with AnginaCardiovascular
- Corticosteroid-responsive dermatosesDermatology
- Cosmetic SurgeryOther
- CoughRespiratory
- COVID-19Infectious Disease
- Cowden SyndromeGenetic DisorderRare
- Cracked ToothOther
- Crigler-Najjar SyndromeMetabolicRare
- Crohn's DiseaseGastrointestinal
- CroupRespiratory
- Cryptococcal MeningitisInfectious Disease
- Cushing's DiseaseEndocrine
- Cushing's SyndromeEndocrine
- Cutaneous CandidiasisDermatology
- Cyanide PoisoningOtherRare
- Cyclic Vomiting SyndromeGastrointestinal
- Cystic FibrosisGenetic DisorderRare
- CystinosisMetabolicRare
- CystinuriaKidney & UrologicalRare
- CystitisKidney & Urological
- Cystitis cysticaKidney & Urological
- Cystoid Macular EdemaOphthalmology
- Cytokine Release SyndromeOther
- Cytomegalovirus InfectionInfectious Disease
- DandruffDermatology
- Deep Vein ThrombosisCardiovascular
- Deep Vein Thrombosis (DVT)Cardiovascular
- DehydrationMetabolic
- DementiaNeurological
- Dementia with agitationNeurological
- Dental Caries Prevention; Nutritional SupportOther
- Dental CavitiesGastrointestinal
- Dental DisorderGastrointestinal
- DepressionMental Health
- DermatitisDermatology
- Dermatitis信号通路检测在评估药物对细胞信号传导影响中的应用十分广泛。通过对特定信号分子的激活或抑制情况进行分析，研究人员可以深入了解药物的作用机制、疗效及潜在毒副作用。以下是信号通路检测在药物研发不同阶段的具体应用及常用检测方法。 ### 1. 信号通路检测在药物研发中的应用 #### A. 药物筛选与活性评价 在新药开发的早期阶段，利用基于信号通路的细胞模型筛选具有生物活性的先导化合物。通过观察药物对特定信号通路（如MAPK、PI3K/Akt、NF-κB等）的调控能力，初步判定其治疗潜力。 #### B. 作用机制研究（MOA） 一旦筛选出具有活性的化合物，需要深入研究其具体的分子靶点及所影响的下游通路。信号通路检测可以揭示药物是如何通过层层传递的信号最终引起细胞生理反应的（如凋亡、增殖或分化）。 #### C. 耐药机制研究 长期用药往往会导致耐药性的产生，这通常与补偿性信号通路的激活有关。通过对比敏感细胞和耐药细胞的信号通路图谱，可以发现耐药的关键信号节点，为联合用药方案提供依据。 #### D. 安全性与毒性预测 某些信号通路（如p53通路的异常激活）是细胞损伤或基因毒性的指标。通过检测这些通路，可以在临床前阶段预测药物的安全性，减少开发风险。 --- ### 2. 常用信号通路检测技术 #### A. 蛋白质水平检测 由于信号传导多涉及蛋白质的磷酸化、乙酰化等翻译后修饰，蛋白质水平的检测是最直接的手段。 * **Western Blot (WB):** 检测特定信号蛋白及其磷酸化状态（如p-Akt/Akt比值）的经典方法。 * **酶联免疫吸附测定 (ELISA):** 用于定量检测细胞裂解液或血清中的关键信号分子或细胞因子。 * **高内涵筛选 (High-Content ScreeningOther
- DiabetesMetabolic
- Diabetes InsipidusEndocrine
- Diabetic AmyotrophyNeurological
- Diabetic Autonomic NeuropathyNeurological
- Diabetic Nerve DamageNeurological
- Diabetic RetinopathyOphthalmology
- Diagnostic Medical ExaminationOther
- DiarrheaGastrointestinal
- Difficulty SwallowingGastrointestinal
- Diffuse Large B-cell LymphomaCancerRare
- DiGeorge SyndromeGenetic DisorderRare
- Digestive DisorderGastrointestinal
- Disorders of Ornithine MetabolismMetabolic
- Disseminated ChorioretinitisOphthalmology
- Disseminated Mycobacterium Avium Complex InfectionInfectious Disease
- Disseminated Valley FeverInfectious Disease
- Dravet SyndromeNeurologicalRare
- Drug-induced constipationGastrointestinal
- Drug-Induced DyskinesiaNeurological
- Drug-Induced HypotensionCardiovascular
- Drug-induced low blood pressureCardiovascular
- Drug-induced neutropeniaBlood Disorders