Directory
Conditions
1,213 conditions. Each page links to drugs that treat it, grants available for patients, and — where it's a rare disease — our sister UniteRare page.
- GastroenteritisGastrointestinal
- Gastroesophageal Reflux DiseaseGastrointestinal
- Gastroesophageal Reflux Disease (GERD)Gastrointestinal
- Gastroesophageal Reflux Disease (GERD) with EsophagitisGastrointestinal
- Gastroesophageal Reflux Disease with EsophagitisGastrointestinal
- Gastrointestinal BleedingGastrointestinal
- Gastrointestinal Stromal TumorCancerRare
- GastroparesisGastrointestinal
- Gaucher DiseaseGenetic DisorderRare
- General Healthcare EncounterOther
- General Medical EncounterOther
- General Medical ExaminationOther
- Generalized Anxiety DisorderMental Health
- Generalized EdemaOther
- Generalized EpilepsyNeurological
- Generalized Idiopathic EpilepsyNeurological
- Genetic Susceptibility to CancerGenetic Disorder
- Genital HerpesInfectious Disease
- Genital WartsReproductive Health
- Giant Cell ArteritisAutoimmuneRare
- Giant Papillary ConjunctivitisOphthalmology
- GiardiasisInfectious Disease
- GingivitisGastrointestinal
- GlaucomaOphthalmology
- Glaucoma SuspectOphthalmology
- Glycoprotein metabolism disorderMetabolic
- GoiterEndocrine
- GonorrheaInfectious Disease
- GoutMetabolic
- Graft-versus-host diseaseAutoimmuneRare
- Gram-negative SepsisInfectious Disease
- Granulomatosis with polyangiitisAutoimmuneRare
- Graves' DiseaseAutoimmune
- Guttate PsoriasisDermatology
- H. pylori InfectionInfectious Disease
- Hair LossDermatology
- Hair Shaft AbnormalityDermatology
- Hairy Cell LeukemiaCancerRare
- Hallucinogen PoisoningOther
- Hay FeverRespiratory
- HCS):** 利用荧光标记和自动化成像，观察蛋白在细胞内的定位（如NF-κB从胞质向胞核的转位）。 * **蛋白质组学/质谱技术:** 对药物处理前后的全细胞蛋白磷酸化水平进行系统性分析。 #### B. 基因水平与转录活性检测 信号通路的下游往往是基因表达的变化。 * **荧光素酶报告基因检测 (Luciferase Reporter Assay):** 将特定信号通路的反应元件（RE）与荧光素酶基因连接。若药物激活该通路，荧光强度增强。这是筛选通路激活剂或抑制剂的高效工具。 * **qPCR:** 检测通路下游靶基因mRNA表达量的变化。 * **转录组测序 (RNA-Seq):** 从整体水平观察药物对信号通路下游所有基因转录的影响。 #### C. 细胞功能水平检测 信号通路的改变最终体现为细胞行为的变化。 * **流式细胞术 (FCM):** 用于检测细胞周期分布、细胞凋亡比例以及胞内磷酸化蛋白。 * **细胞增殖与迁移实验 (CCK-8Other
- Head and Neck CancerCancer
- Head LiceInfectious Disease
- Healthcare Access IssuesOther
- Heart ArrhythmiaCardiovascular
- Heart AttackCardiovascular
- Heart DiseaseCardiovascular
- Heart FailureCardiovascular
- Heart Valve ReplacementCardiovascular
- Heavy and Irregular PeriodsReproductive Health
- Heavy Menstrual BleedingReproductive Health
- Helicobacter pylori InfectionInfectious Disease
- HemangiomaDermatology
- HemochromatosisGenetic Disorder
- Hemophagocytic LymphohistiocytosisBlood DisordersRare
- Hemophilia ABlood DisordersRare
- Hemophilia BBlood DisordersRare
- HemorrhageBlood Disorders
- HemorrhoidsGastrointestinal
- Heparin-Induced ThrombocytopeniaBlood Disorders
- Hepatopulmonary SyndromeGastrointestinal
- Hepatorenal SyndromeGastrointestinal
- Hereditary AmyloidosisGenetic DisorderRare
- Hereditary AngioedemaAutoimmuneRare
- Hereditary Erythropoietic PorphyriaGenetic DisorderRare
- Hereditary HemochromatosisMetabolic
- Hereditary HypophosphatemiaGenetic Disorder
- Hereditary NeutropeniaBlood Disorders
- Hereditary transthyretin-mediated amyloidosisGenetic Disorder
- Herpes EncephalitisInfectious Disease
- Herpes Eye InfectionOphthalmology
- Herpes SimplexInfectious Disease
- Herpes Simplex InfectionInfectious Disease
- Hidradenitis SuppurativaDermatology
- High Blood PressureCardiovascular
- High CholesterolMetabolic
- High PotassiumKidney & Urological
- High TriglyceridesOther
- HistoplasmosisInfectious DiseaseRare
- History of Stroke or TIANeurological
- History of SurgeryOther
- HIV DiseaseInfectious Disease
- HIV ExposureInfectious Disease
- HIV-1 InfectionInfectious Disease
- HIV/AIDSInfectious Disease
- HivesDermatology
- Hodgkin LymphomaCancerRare
- HomocystinuriaMetabolicRare
- Hookworm InfectionInfectious DiseaseRare
- Huntington's DiseaseNeurological
- Hurler SyndromeGenetic DisorderRare
- HypercalcemiaEndocrine
- HyperchylomicronemiaMetabolic
- HypergastrinemiaEndocrine
- HyperinsulinismEndocrine
- HyperkalemiaMetabolic
- HyperkeratosisDermatology
- HyperlipidemiaMetabolic
- HypermagnesemiaMetabolic
- HyperparathyroidismEndocrine