Ayvakit
Generic: avapritinib
- Manufacturer
- Blueprint
- NDC
- 72064-110
- RxCUI
- 2272112
- Route
- ORAL
- ICD-10 indication
- C49.A0
Affordability Check
How much will you actually pay for Ayvakit?
In 30 seconds, see every legitimate way to afford Ayvakit — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.
About Ayvakit
What is this medication?
Ayvakit is a prescription medication primarily used to treat adults with two specific medical conditions. First, it is approved for the treatment of advanced systemic mastocytosis, which is a rare blood disorder caused by the buildup of mast cells in the body's organs. It is also used for indolent systemic mastocytosis in patients whose symptoms are not well-controlled by other treatments. By targeting the underlying cause of these conditions, the drug helps to reduce symptoms and the overall burden of the disease.
Additionally, Ayvakit is indicated for the treatment of adults with a specific type of stomach or intestinal cancer called gastrointestinal stromal tumor, or GIST. This application is specifically for tumors that cannot be removed by surgery or have spread to other parts of the body and possess a particular genetic change known as a PDGFRA exon 18 mutation. As a kinase inhibitor, the medication works by blocking certain proteins that signal cancer cells to grow and divide, thereby slowing the progression of the disease.
Copay & patient assistance
- Patient Copay Amount: As little as $0
- Maximum Annual Benefit Limit: $25,000
- Core Eligibility Restrictions: Patients must have commercial insurance (provided through an employer or purchased independently); must be a U.S. resident aged 18 or older; requires enrollment by a healthcare provider and patient consent/authorization.
- RxBIN, PCN, and Group numbers: Not Publicly Available
External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.
Compare pricing elsewhere
RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.
Cost Plus Drug Company
Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for avapritinib.
Browse Cost Plus medications →
GoodRx
Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.
Lookup Ayvakit →
NeedyMeds
Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.
Search for avapritinib →
RxAssist
PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.
Search PAPs →
We deep-link because transparency helps patients. None of these partners pay RxCopays.
Conditions we've indexed resources for
Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.
Medicare Part D coverage
How Ayvakit appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-08-31).
Covered by plans
49%
2,702 of 5,499 plans
Most common tier
Tier 5
On 78% of covering formularies
Prior authorization required
100%
of covering formularies
| Tier | Formularies on this tier | Share |
|---|---|---|
| Tier 1 (preferred generic) | 40 | 19% |
| Tier 2 (generic) | 1 | 0% |
| Tier 4 (non-preferred brand) | 4 | 2% |
| Tier 5 (specialty) | 163 | 78% |
Step therapy: 0% of formularies
Quantity limits: 97% of formularies
Coverage breadth: 208 of 65 formularies
How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).
Prior authorization & coverage
| Payer | PA | Step therapy | Copay tier |
|---|---|---|---|
— Medicare Part D | — | — | — |
Related drugs
Xospata
Treats same condition · gilteritinib
Mercaptopurine
Treats same condition · Mercaptopurine
Elliotts B
Treats same condition · sodium cation, sodium bicarbonate, anhydrous dextrose, magnesium sulfate, potassium chloride, calcium chloride, sodium phosphate
Mitoxantrone
Treats same condition · Mitoxantrone
Isoniazid
Treats same condition · Isoniazid
Bendamustine
Treats same condition · BENDAMUSTINE HYDROCHLORIDE
TIBSOVO
Treats same condition · ivosidenib
Tasigna
Treats same condition · nilotinib
Allopurinol
Treats same condition · Allopurinol
GRAFAPEX
Treats same condition · treosulfan
How this page is sourced
- Drug identity verified against openFDA NDC Directory.
- Label text (when shown) originates from NLM DailyMed.
- Copay and assistance URLs verified periodically; if you hit a broken link, tell us.
Rare-disease navigation (specialists, trials, patient communities)
Ayvakit treats 2 rare conditions. For in-depth disease pages on our sister site:
UniteRare.org is our sister site for rare-disease navigation — same editorial team, same accuracy standards.