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Choletec

Generic: Mebrofenin

Verified·Apr 23, 2026
Manufacturer
Bracco
NDC
0270-0083
Route
INTRAVENOUS
ICD-10 indication
K81.0

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About Choletec

What is this medication? Choletec is a prescription radiopharmaceutical agent containing the active ingredient technetium Tc 99m mebrofenin. It is primarily used as a diagnostic tool in medical imaging procedures known as hepatobiliary scans, or HIDA scans. After being injected into the bloodstream, the medication is quickly absorbed by the liver and then secreted into the bile, allowing healthcare providers to visualize the function of the liver, gallbladder, and the surrounding bile duct system using a gamma camera.

This medication is specifically indicated for the diagnosis of several gallbladder and liver conditions, such as acute cholecystitis, which is the sudden inflammation of the gallbladder. It can also help detect blockages in the bile ducts, identify bile leaks after surgery, or assess the overall flow of bile from the liver into the small intestine. Because it contains a small amount of radioactive material, it is only administered by trained professionals in clinical or hospital settings for diagnostic purposes rather than for treating a specific disease.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

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Prescribing information

From the FDA-approved label for Choletec. Official source: DailyMed (NLM) · Label effective Nov 29, 2025

Indications and usage
INDICATIONS AND USAGE Technetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent.
Dosage and administration
DOSAGE AND ADMINISTRATION The suggested intravenous dose range of Technetium Tc 99m Mebrofenin in the average patient (70 kg) is: Nonjaundiced patient: 74-185 MBq (2-5 mCi) Patient with serum bilirubin level greater than 1.5 mg/dL: 111-370 MBq (3-10 mCi) The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration. The patient should be in a fasting state, 4 hours is preferable. False positives (non-visualization) may result if the gallbladder has been emptied by ingestion of food. An interval of at least 24 hours should be allowed before repeat examination. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
Contraindications
CONTRAINDICATIONS Hypersensitivity to this compound.
Warnings
WARNINGS The theoretical possibility of allergic reactions should be considered in patients who receive multiple doses.
Adverse reactions
ADVERSE REACTIONS Urticaria and rash have been rarely reported with the use of Technetium Tc 99m Mebrofenin since market introduction. Rare cases of chills and nausea have been reported with related compounds. Infrequently, death has been reported in association with the use of this class of agents.
Use in pregnancy
Pregnancy Animal reproduction studies have not been conducted with Technetium Tc 99m Mebrofenin. It is also not known whether Technetium Tc 99m Mebrofenin can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Technetium Tc 99m Mebrofenin should be given to a pregnant woman only if the expected benefits to be gained clearly outweigh the potential hazards.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.