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Econazole Nitrate

Generic: Econazole nitrate

Verified·Apr 23, 2026
Manufacturer
Almirall
NDC
68788-8174
ICD-10 indication
B35.3

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About Econazole Nitrate

What is this medication? Econazole nitrate is a topical antifungal medication primarily used to treat various types of fungal and yeast infections of the skin. It belongs to a class of drugs known as azole antifungals, which work by slowing the growth of fungus and disrupting the integrity of fungal cell membranes. Health care providers commonly prescribe this cream to manage conditions such as athlete's foot, jock itch, and ringworm. Beyond these common fungal issues, econazole nitrate is also utilized to treat cutaneous candidiasis and tinea versicolor, a condition that causes small patches of light or dark skin. The medication is typically applied directly to the affected area once or twice daily as instructed by a physician. It is important for patients to continue using the cream for the full duration prescribed, even if symptoms like itching or redness improve quickly, to prevent the infection from recurring.

Copay & patient assistance

  • Patient Copay Amount: Not Publicly Available
  • Maximum Annual Benefit Limit: Not Publicly Available
  • Core Eligibility Restrictions: Not Publicly Available
  • RxBIN, PCN, and Group numbers: Not Publicly Available

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Prescribing information

From the FDA-approved label for Econazole Nitrate. Official source: DailyMed (NLM) · Label effective Apr 10, 2026

Indications and usage
INDICATIONS AND USAGE Econazole nitrate cream is indicated for topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
Dosage and administration
DOSAGE AND ADMINISTRATION Sufficient econazole nitrate cream, 1%, should be applied to cover affected areas once daily in patients with tinea pedis, tinea cruris, tinea corporis, and tinea versicolor, and twice daily (morning and evening) in patients with cutaneous candidiasis. Early relief of symptoms is experienced by the majority of patients and clinical improvement may be seen fairly soon after treatment is begun; however, candidal infections and tinea cruris and corporis should be treated for two weeks and tinea pedis for one month in order to reduce the possibility of recurrence. If a patient shows no clinical improvement after the treatment period, the diagnosis should be redetermined. Patients with tinea versicolor usually exhibit clinical and mycological clearing after two weeks of treatment.
Contraindications
CONTRAINDICATIONS Econazole nitrate cream is contraindicated in individuals who have shown hypersensitivity to any of its ingredients.
Warnings
WARNINGS Econazole nitrate cream is not for ophthalmic use.
Drug interactions
Drug Interactions Warfarin Concomitant administration of econazole and warfarin has resulted in enhancement of anticoagulation effect. Most cases reported product application with use under occlusion, genital application, or application to large body surface area which may increase the systemic absorption of econazole nitrate. Monitoring of International Normalized Ratio (INR) and/or prothrombin time may be indicated especially for patients who apply econazole to large body surface areas, in the genital area, or under occlusion.
Adverse reactions
ADVERSE REACTIONS During clinical trials, approximately 3% of patients treated with econazole nitrate cream 1% reported side effects thought possibly to be due to the drug, consisting mainly of burning, itching, stinging and erythema. One case of pruritic rash has also been reported.
Use in pregnancy
Pregnancy Econazole nitrate has not been shown to be teratogenic when administered orally to mice, rabbits or rats. Fetotoxic or embryotoxic effects were observed in Segment I oral studies with rats receiving 10 to 40 times the human dermal dose. Similar effects were observed in Segment II or Segment III studies with mice, rabbits and/or rats receiving oral doses 80 or 40 times the human dermal dose. Econazole nitrate should be used in the first trimester of pregnancy only when the physician considers it essential to the welfare of the patient. The drug should be used during the second and third trimesters of pregnancy only if clearly needed.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Medicare Part D coverage

How Econazole Nitrate appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-04-30).

Covered by plans

41%

2,247 of 5,509 plans

Most common tier

Tier 2

On 30% of covering formularies

Prior authorization required

0%

of covering formularies

TierFormularies on this tierShare
Tier 1 (preferred generic)84
29%
Tier 2 (generic)88
30%
Tier 3 (preferred brand)50
17%
Tier 4 (non-preferred brand)68
23%

Step therapy: 0% of formularies

Quantity limits: 67% of formularies

Coverage breadth: 290 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

PayerPAStep therapyCopay tier

Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.