How much does Humulin R U-500, Humulin R U-500 KwikPen cost?

Pricing for Humulin R U-500, Humulin R U-500 KwikPen varies by insurance plan, dose, and pharmacy. Our database does not show a fixed cost because prices change faster than we can verify. For current pharmacy prices, check your insurance's formulary tier (in the prior-authorization section), use the GoodRx or Cost Plus Drugs deep links on this page, or ask your pharmacist to run a test claim. If a copay card is listed, it usually drops the out-of-pocket significantly for commercial insurance.

Does Humulin R U-500, Humulin R U-500 KwikPen need prior authorization?

Humulin R U-500, Humulin R U-500 KwikPen appears on 1 payer formulary in our database. PA requirements vary by payer — see the prior-authorization table on this page for specifics. In general, specialty and brand-name drugs are more likely to require PA than generic equivalents.

Is there a copay card or patient assistance program for Humulin R U-500, Humulin R U-500 KwikPen?

We haven't verified an active copay card or PAP for Humulin R U-500, Humulin R U-500 KwikPen in our current data. Check NeedyMeds or RxAssist for independent directories, or submit what you find via our "Report a broken link" form.

Humulin R U-500, Humulin R U-500 KwikPen

Unverified·never

Manufacturer: Eli Lilly
ICD-10 indication: E11.9

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How much will you actually pay for Humulin R U-500, Humulin R U-500 KwikPen?

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About Humulin R U-500, Humulin R U-500 KwikPen

What is this medication? Humulin R U-500 and the Humulin R U-500 KwikPen are concentrated forms of regular human insulin used to manage blood sugar levels in patients with diabetes mellitus. This medication is specifically designed for individuals who have severe insulin resistance and require high daily doses, generally more than 200 units per day. Because it contains 500 units of insulin per milliliter, it is five times more potent than standard insulin, allowing patients to inject a smaller volume of liquid to receive the necessary high dose.

The medication serves a dual purpose by acting as both a mealtime insulin to cover glucose spikes and a basal insulin to maintain steady levels throughout the day and night. It is available in a vial for use with specific U-500 syringes or as a pre-filled KwikPen to ensure accurate dosing and ease of use. By concentrating the insulin, this treatment helps simplify the injection routine for those who would otherwise need multiple high-volume injections of less concentrated products.

Copay & patient assistance

Patient Copay Amount: $35 per 30-day supply for all covered Lilly insulins.
Maximum Annual Benefit Limit: Up to $16,000 per calendar year for patients with commercial insurance coverage; Program is also limited to 14–16 prescription fills per calendar year depending on the patient's insurance coverage status.
Core Eligibility Restrictions: Patients must be 18 years of age or older and a resident of the United States or its territories. Individuals enrolled in any state or federal government-funded healthcare program—including Medicare, Medicaid, TRICARE, VA, or DoD—are ineligible. The program is also unavailable to those enrolled in Alternate Funding Programs (AFPs).
RxBIN, PCN, and Group numbers: Not Publicly Available.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for Humulin R U-500, Humulin R U-500 KwikPen.

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GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

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NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

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RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

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We deep-link because transparency helps patients. None of these partners pay RxCopays.

Prior authorization & coverage

Payer	PA	Step therapy	Copay tier
— Medicare Part D	—	—	—

Payer

Step therapy

Copay tier

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Medicare Part D

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How this page is sourced

Drug identity verified against openFDA NDC Directory.
Label text (when shown) originates from NLM DailyMed.
Copay and assistance URLs verified periodically; if you hit a broken link, tell us.