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Ionite APF

Generic: Sodium Fluoride

Verified·Apr 23, 2026
Manufacturer
Dharma Research, Inc.
NDC
53045-200
RxCUI
245593
Route
DENTAL
ICD-10 indication
Z29.3

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About Ionite APF

What is this medication? Ionite APF is a prescription-strength topical fluoride treatment, specifically categorized as an acidulated phosphate fluoride. It is primarily used to prevent dental caries, or cavities, by strengthening the outer layer of the teeth known as enamel. By increasing the uptake of fluoride into the tooth structure, it helps the enamel become more resistant to the corrosive effects of acids produced by plaque bacteria and sugars in the diet. This medication is commonly applied by dental professionals in a clinical setting or prescribed for home use for individuals at a high risk of developing tooth decay. Beyond its role in cavity prevention, this treatment is also effective in promoting the remineralization of areas where the enamel has begun to soften. It works by integrating fluoride ions into the crystalline structure of the teeth, which not only repairs early damage but also inhibits the further breakdown of tooth minerals. It is particularly beneficial for patients with orthodontic appliances, dry mouth conditions, or those who have difficulty maintaining optimal oral hygiene. Proper use of the gel or rinse helps maintain long-term dental health and reduces the need for more invasive restorative procedures.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

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Prescribing information

From the FDA-approved label for Ionite APF. Official source: DailyMed (NLM) · Label effective Nov 15, 2020

Warnings and precautions
Keep out of the reach of children. Do not swallow. If product is accidentally swallowed in quantities greater than would normally occur with a treatment gel, seek medical help or contact a Poison Control Center right away. Do not use on patients with an allergy Fluoride. Ionite APF Gel contains artificial color, confirm that no kno.wn patient allergies exist. For professional use only.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

PayerPAStep therapyCopay tier

Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.