How much does Jynarque, JYNARQUE cost?

Pricing for Jynarque, JYNARQUE varies by insurance plan, dose, and pharmacy. Our database does not show a fixed cost because prices change faster than we can verify. For current pharmacy prices, check your insurance's formulary tier (in the prior-authorization section), use the GoodRx or Cost Plus Drugs deep links on this page, or ask your pharmacist to run a test claim. If a copay card is listed, it usually drops the out-of-pocket significantly for commercial insurance.

Does Jynarque, JYNARQUE need prior authorization?

Jynarque, JYNARQUE appears on 1 payer formulary in our database. PA requirements vary by payer — see the prior-authorization table on this page for specifics. In general, specialty and brand-name drugs are more likely to require PA than generic equivalents.

Is there a copay card or patient assistance program for Jynarque, JYNARQUE?

Yes — the manufacturer copay card link is available on this page. A patient assistance program is also available for qualifying patients. Eligibility typically depends on insurance type and income. Click the CTA buttons above to apply directly through the manufacturer's portal.

What is Jynarque, JYNARQUE used to treat?

Jynarque, JYNARQUE is indicated for Kidney Disease, Polycystic Kidney Disease. Click any condition name on this page for more detail.

Jynarque, JYNARQUE

Unverified·never

Manufacturer: Otsuka
ICD-10 indication: Q61.3

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About Jynarque, JYNARQUE

What is this medication?

Jynarque is a prescription medicine that contains the active ingredient tolvaptan. It is specifically indicated to slow the decline of kidney function in adults who are at risk of rapidly progressing autosomal dominant polycystic kidney disease, often referred to as ADPKD. This genetic condition is characterized by the development of numerous fluid-filled cysts in the kidneys, which can cause the organs to enlarge and eventually lead to kidney failure. By slowing the rate of kidney function decline, the medication helps manage the progression of this chronic disease.

The medication works by acting as a selective vasopressin V2-receptor antagonist, which helps to reduce the growth and formation of kidney cysts. Because Jynarque carries a risk of serious and potentially fatal liver injury, it is only available through a restricted distribution program called the Jynarque REMS. Patients must undergo regular blood tests to monitor their liver health before and during treatment. Common side effects associated with the drug include increased thirst, frequent urination, and needing to urinate more often during the night.

Copay & patient assistance

Patient Copay Amount: As little as $0 per 28-day supply
Maximum Annual Benefit Limit: $9,200 (for 2025)
Core Eligibility Restrictions: Must have commercial insurance; not eligible if covered by any state or federal healthcare program (including Medicare Part D, Medicaid, Medigap, VA, DOD, or TRICARE); must be 18 years of age or older; must be a resident of the U.S. or Puerto Rico; cannot be combined with other offers or pharmacy benefit manager programs like "maximizers" or "accumulators"; specific state exclusions apply to Massachusetts (starting May 13, 2025) and California (starting August 13, 2025)
RxBIN, PCN, and Group numbers: Not Publicly Available (A physical copay card is not required as the benefit is applied directly through REMS-certified Specialty Pharmacies)

Copay card →Patient Assistance Program →

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for Jynarque, JYNARQUE.

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GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

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NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

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RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

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We deep-link because transparency helps patients. None of these partners pay RxCopays.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

Payer	PA	Step therapy	Copay tier
— Medicare Part D	Yes	—	—

Payer

Step therapy

Copay tier

—

Medicare Part D

Yes

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Related drugs

How this page is sourced

Drug identity verified against openFDA NDC Directory.
Label text (when shown) originates from NLM DailyMed.
Copay and assistance URLs verified periodically; if you hit a broken link, tell us.