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Linzess

Generic: linaclotide

Verified·Oct 26, 2026
Manufacturer
AbbVie
NDC
0456-1201
RxCUI
1307409
Route
ORAL
ICD-10 indication
K58.1

Affordability Check

How much will you actually pay for Linzess?

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About Linzess

What is this medication? Linzess is a prescription drug primarily used to treat certain types of digestive issues, specifically irritable bowel syndrome with constipation and chronic idiopathic constipation. It contains the active ingredient linaclotide and works by increasing the secretion of fluid in your intestines. This process helps to soften the stool and speed up bowel movements, which can alleviate symptoms like bloating and abdominal pain while promoting more regular bathroom habits.

This medication is typically taken once a day on an empty stomach, at least thirty minutes before the first meal. It is designed for adults, though it has also been approved for use in children and adolescents aged six to seventeen years who suffer from functional constipation. By acting locally in the gut, Linzess helps reduce the discomfort associated with persistent constipation without being absorbed significantly into the bloodstream.

Copay & patient assistance

  • Patient Copay Amount: As little as $30 for a 30, 60, or 90-day supply.
  • Maximum Annual Benefit Limit: $2,280.00 per calendar year.
  • Core Eligibility Restrictions: Valid only for patients with commercial prescription insurance; must be 6 years of age or older; not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs (including TRICARE and VA); not valid for cash-paying patients; offer good only in the USA and Puerto Rico; maximum of twelve (12) prescription fills per calendar year.
  • RxBIN, PCN, and Group numbers: Not Publicly Available

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

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Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Medicare Part D coverage

How Linzess appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-08-31).

Covered by plans

35%

1,902 of 5,499 plans

Most common tier

Tier 3

On 75% of covering formularies

Prior authorization required

0%

of covering formularies

TierFormularies on this tierShare
Tier 1 (preferred generic)59
18%
Tier 2 (generic)7
2%
Tier 3 (preferred brand)247
75%
Tier 4 (non-preferred brand)15
5%

Step therapy: 0% of formularies

Quantity limits: 98% of formularies

Coverage breadth: 328 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

PayerPAStep therapyCopay tier

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Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.