How much does Nucala cost?

Pricing for Nucala varies by insurance plan, dose, and pharmacy. Our database does not show a fixed cost because prices change faster than we can verify. For current pharmacy prices, check your insurance's formulary tier (in the prior-authorization section), use the GoodRx or Cost Plus Drugs deep links on this page, or ask your pharmacist to run a test claim. If a copay card is listed, it usually drops the out-of-pocket significantly for commercial insurance.

Does Nucala need prior authorization?

Nucala appears on 1 payer formulary in our database. PA requirements vary by payer — see the prior-authorization table on this page for specifics. In general, specialty and brand-name drugs are more likely to require PA than generic equivalents.

Is there a copay card or patient assistance program for Nucala?

Yes — the manufacturer copay card link is available on this page. A patient assistance program is also available for qualifying patients. Eligibility typically depends on insurance type and income. Click the CTA buttons above to apply directly through the manufacturer's portal.

What is Nucala used to treat?

Nucala (generic: mepolizumab) is indicated for Granulomatosis with polyangiitis, Severe Asthma, Nasal Polyps and 3 other conditions. Click any condition name on this page for more detail.

Does Nucala have a generic version?

The generic name for Nucala is mepolizumab. Whether a generic is currently available depends on patent status — check the FDA Orange Book or ask your pharmacist. Generics are often substantially cheaper than brand-name drugs.

Nucala

Generic: mepolizumab

Verified·Oct 26, 2026

Manufacturer: GlaxoSmithKline
NDC: 0173-0881
RxCUI: 1720601
Route: SUBCUTANEOUS
ICD-10 indication: J45.50

Affordability Check

How much will you actually pay for Nucala?

In 30 seconds, see every legitimate way to afford Nucala — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.

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About Nucala

What is this medication? Nucala is a prescription biologic medication, known generically as mepolizumab, that is primarily used as an add-on maintenance treatment for people with severe eosinophilic asthma. It works by targeting and reducing the levels of eosinophils, which are a type of white blood cell that can cause inflammation in the lungs and airways when present in high amounts. By lowering these levels, the medication helps to prevent severe asthma attacks and improve overall breathing for patients who do not get enough relief from their regular asthma medicines alone.

In addition to treating asthma, Nucala is used to manage several other conditions characterized by high eosinophil levels. These include chronic rhinosinusitis with nasal polyps in adults, as well as rarer conditions such as eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome. The medication is administered as an injection under the skin every four weeks, either by a healthcare professional or through a self-injection device at home after proper training. It is not intended for use in treating sudden breathing problems or acute asthma attacks.

Copay & patient assistance

Patient Copay Amount: As little as $0
Maximum Annual Benefit Limit: Not Publicly Available
Core Eligibility Restrictions: Patients must have commercial medical or prescription insurance; must be a resident of the U.S., District of Columbia, Puerto Rico, or the U.S. Virgin Islands; must not be enrolled in any federal or state government-funded program (including Medicare Part B, Medicare Part D, Medicaid, Medigap, VA, DoD, or TriCare); residents of Massachusetts and Rhode Island are ineligible for administrative fee reimbursement.
RxBIN, PCN, and Group numbers: Not Publicly Available

Copay card →Patient Assistance Program →

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for mepolizumab.

Browse Cost Plus medications →

GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

Lookup Nucala →

NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

Search for mepolizumab →

RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

Search PAPs →

We deep-link because transparency helps patients. None of these partners pay RxCopays.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Medicare Part D coverage

How Nucala appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-08-31).

Covered by plans

48%

2,656 of 5,499 plans

Most common tier

Tier 5

On 72% of covering formularies

Prior authorization required

100%

of covering formularies

Tier	Formularies on this tier	Share
Tier 1 (preferred generic)	38	22%
Tier 2 (generic)	2	1%
Tier 4 (non-preferred brand)	7	4%
Tier 5 (specialty)	123	72%

Step therapy: 0% of formularies

Quantity limits: 92% of formularies

Coverage breadth: 170 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

Payer	PA	Step therapy	Copay tier
— Medicare Part D	Yes	—	—

Payer

Step therapy

Copay tier

—

Medicare Part D

Yes

—

Related drugs

How this page is sourced

Drug identity verified against openFDA NDC Directory.
Label text (when shown) originates from NLM DailyMed.
Copay and assistance URLs verified periodically; if you hit a broken link, tell us.

Rare-disease navigation (specialists, trials, patient communities)

Nucala treats a rare condition. For in-depth disease pages on our sister site:

UniteRare · Granulomatosis with polyangiitis

UniteRare.org is our sister site for rare-disease navigation — same editorial team, same accuracy standards.