Ohtuvayre
Generic: ensifentrine
- Manufacturer
- Verona
- NDC
- 83034-003
- RxCUI
- 2687221
- Route
- RESPIRATORY (INHALATION)
- ICD-10 indication
- J44.9
Affordability Check
How much will you actually pay for Ohtuvayre?
In 30 seconds, see every legitimate way to afford Ohtuvayre — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.
About Ohtuvayre
What is this medication? Ohtuvayre is a prescription medication known generically as ensifentrine that is used for the maintenance treatment of chronic obstructive pulmonary disease, commonly called COPD, in adults. It is the first medication in its class to offer a dual mechanism of action, functioning as both a bronchodilator to open the airways and a non-steroidal anti-inflammatory to reduce swelling in the lungs. It is meant for long-term daily use to help manage symptoms and improve overall lung function rather than treating acute breathing emergencies.
The medication is delivered directly to the lungs through a standard jet nebulizer twice a day. By inhibiting specific enzymes called phosphodiesterase 3 and 4, Ohtuvayre helps to relax smooth muscles in the respiratory tract while decreasing the inflammatory response that often complicates COPD. This combined approach helps patients breathe more easily and can be used as a standalone maintenance therapy or alongside other existing COPD treatments.
Copay & patient assistance
- Patient Copay Amount: As little as $0 per month
- Maximum Annual Benefit Limit: Not Publicly Available
- Core Eligibility Restrictions: Must have commercial insurance and be enrolled in Verona Pathway Plus; patients enrolled in federal, state, or government-funded healthcare programs (including Medicare and Medicaid) are ineligible; valid only in the U.S. and where not prohibited by law.
- RxBIN, PCN, and Group numbers: Not Publicly Available
External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.
Compare pricing elsewhere
RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.
Cost Plus Drug Company
Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for ensifentrine.
Browse Cost Plus medications →
GoodRx
Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.
Lookup Ohtuvayre →
NeedyMeds
Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.
Search for ensifentrine →
RxAssist
PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.
Search PAPs →
We deep-link because transparency helps patients. None of these partners pay RxCopays.
Conditions we've indexed resources for
Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.
Medicare Part D coverage
How Ohtuvayre appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-08-31).
Covered by plans
8%
448 of 5,499 plans
Most common tier
Tier 5
On 80% of covering formularies
Prior authorization required
100%
of covering formularies
| Tier | Formularies on this tier | Share |
|---|---|---|
| Tier 1 (preferred generic) | 3 | 20% |
| Tier 5 (specialty) | 12 | 80% |
Step therapy: 0% of formularies
Quantity limits: 80% of formularies
Coverage breadth: 15 of 65 formularies
How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).
Prior authorization & coverage
| Payer | PA | Step therapy | Copay tier |
|---|---|---|---|
— Medicare Part D | Yes | — | — |
Related drugs
Dupixent
Treats same condition · Dupilumab
Prednisolone Sodium Phosphate Oral Solution
Treats same condition · prednisoLONE sodium phosphate
Prednisone delayed release
Treats same condition · Prednisone
ROFLUMILAST
Treats same condition · roflumilast
Orapred ODT
Treats same condition · prednisolone sodium phosphate
Oxygen Size B, Oxygen Size C, Oxygen Size D, Oxygen Size E, Oxygen Size M, Oxygen Size F, Oxygen Size H, Oxygen Size T, Oxygen Size 400
Treats same condition
Arformoterol Tartrate
Treats same condition · Arformoterol Tartrate
IPRATROPIUM BROMIDE
Treats same condition · Ipratropium Bromide
posfrea
Treats same condition · palonosetron
Fluticasone Propionate and Salmeterol DISKUS
Treats same condition · fluticasone propionate and salmeterol
How this page is sourced
- Drug identity verified against openFDA NDC Directory.
- Label text (when shown) originates from NLM DailyMed.
- Copay and assistance URLs verified periodically; if you hit a broken link, tell us.