How much does Orphenadrine Citrate ER cost?

Pricing for Orphenadrine Citrate ER varies by insurance plan, dose, and pharmacy. Our database does not show a fixed cost because prices change faster than we can verify. For current pharmacy prices, check your insurance's formulary tier (in the prior-authorization section), use the GoodRx or Cost Plus Drugs deep links on this page, or ask your pharmacist to run a test claim. If a copay card is listed, it usually drops the out-of-pocket significantly for commercial insurance.

Does Orphenadrine Citrate ER need prior authorization?

Orphenadrine Citrate ER appears on 1 payer formulary in our database. PA requirements vary by payer — see the prior-authorization table on this page for specifics. In general, specialty and brand-name drugs are more likely to require PA than generic equivalents.

Is there a copay card or patient assistance program for Orphenadrine Citrate ER?

We haven't verified an active copay card or PAP for Orphenadrine Citrate ER in our current data. Check NeedyMeds or RxAssist for independent directories, or submit what you find via our "Report a broken link" form.

Does Orphenadrine Citrate ER have a generic version?

The generic name for Orphenadrine Citrate ER is Orphenadrine Citrate. Whether a generic is currently available depends on patent status — check the FDA Orange Book or ask your pharmacist. Generics are often substantially cheaper than brand-name drugs.

Orphenadrine Citrate ER

Generic: Orphenadrine Citrate

Verified·Apr 23, 2026

Manufacturer: Bausch Health
NDC: 80425-0117
RxCUI: 994521
Route: ORAL
ICD-10 indication: M62.40

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About Orphenadrine Citrate ER

What is this medication? Orphenadrine citrate ER is a skeletal muscle relaxant primarily used to treat discomfort associated with acute, painful musculoskeletal conditions. It is specifically designed to help relieve muscle spasms and tension caused by injuries such as strains or sprains. Rather than acting directly on the skeletal muscles, this medication works by affecting the central nervous system to help reduce pain sensations and promote relaxation.

This medication is generally prescribed as part of a broader recovery plan that includes rest and physical therapy to improve mobility and healing. Because it is an extended-release formulation, the drug is gradually released into the bloodstream over several hours, providing prolonged relief throughout the day or night. It is intended for short-term use to manage the initial stages of muscle pain and should be used exactly as directed by a healthcare provider.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for Orphenadrine Citrate.

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GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

Lookup Orphenadrine Citrate ER →

NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

Search for Orphenadrine Citrate →

RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

Search PAPs →

We deep-link because transparency helps patients. None of these partners pay RxCopays.

Prescribing information

From the FDA-approved label for Orphenadrine Citrate ER. Official source: DailyMed (NLM) · Label effective Dec 31, 2024

Indications and usage

3. Indications and Usage Section INDICATIONS AND USAGE Orphenadrine citrate extended-release tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions.

Dosage and administration

10. Dosage and Administration Section DOSAGE AND ADMINISTRATION Adults Two tablets per day; one in the morning and one in the evening.

Contraindications

4. Contraindications Orphenadrine citrate extended-release tablets are contraindicated in patients with glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcers, prostatic hypertrophy or obstruction of the bladder neck, cardio-spasm (mega-esophagus) and myasthenia gravis. Orphenadrine citrate tablets are contraindicated in patients who have demonstrated a previous hypersensitivity to the drug.

Warnings

5. Warnings Some patients may experience transient episodes of light-headedness, dizziness or syncope. Orphenadrine may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; ambulatory patients should therefore be cautioned accordingly.

Adverse reactions

7. Adverse Reactions Adverse reactions of orphenadrine are mainly due to the mild anticholinergic action of orphenadrine, and are usually associated with higher dosage. Dryness of the mouth is usually the first adverse effect to appear. When the daily dose is increased, possible adverse effects include: tachycardia, palpitation, urinary hesitancy or retention, blurred vision, dilatation of pupils, increased ocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, hypersensitivity reactions, pruritus, hallucinations, agitation, tremor, gastric irritation, and rarely urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of mental confusion. These adverse reactions can usually be eliminated by reduction in dosage. Very rare cases of aplastic anemia associated with the use of orphenadrine tablets have been reported. No causal relationship has been established.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Medicare Part D coverage

How Orphenadrine Citrate ER appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-04-30).

Covered by plans

427 of 5,509 plans

Most common tier

Tier 2

On 34% of covering formularies

Prior authorization required

36%

of covering formularies

Tier	Formularies on this tier	Share
Tier 1 (preferred generic)	23	33%
Tier 2 (generic)	24	34%
Tier 3 (preferred brand)	19	27%
Tier 4 (non-preferred brand)	4	6%

Step therapy: 0% of formularies

Quantity limits: 0% of formularies

Coverage breadth: 70 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

Payer	PA	Step therapy	Copay tier
— Medicare Part D	—	—	—

Payer

Step therapy

Copay tier

—

Medicare Part D

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Related drugs

How this page is sourced

Drug identity verified against openFDA NDC Directory.
Label text (when shown) originates from NLM DailyMed.
Copay and assistance URLs verified periodically; if you hit a broken link, tell us.