Pegasys
Generic: peginterferon alfa-2a
- Manufacturer
- Roche
- NDC
- 82154-0449
- RxCUI
- 351270
- Route
- SUBCUTANEOUS
- ICD-10 indication
- B18.1
Affordability Check
How much will you actually pay for Pegasys?
In 30 seconds, see every legitimate way to afford Pegasys — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.
About Pegasys
What is this medication? Pegasys is an injectable prescription medicine that contains the active ingredient peginterferon alfa-2a. It is primarily used to treat chronic hepatitis C and chronic hepatitis B, which are viral infections that cause inflammation and damage to the liver. For hepatitis C, it is often prescribed for adults with compensated liver disease and is frequently used in combination with other antiviral medications. For hepatitis B, it can be used in both adults and children who show evidence of viral replication and liver inflammation.
The medication functions by mimicking the actions of natural interferons, which are proteins the body produces to fight off viral invaders. By enhancing the immune system response and interfering with the ability of the virus to reproduce, Pegasys helps to decrease the viral load in a patient's system. It is typically administered as a subcutaneous injection once per week, and the duration of treatment varies depending on the specific type of virus and the patient's individual response to the drug.
Copay & patient assistance
- Patient Copay Amount: Not Publicly Available
- Maximum Annual Benefit Limit: Not Publicly Available
- Core Eligibility Restrictions: Not Publicly Available
- RxBIN, PCN, and Group numbers: Not Publicly Available
External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.
Compare pricing elsewhere
RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.
Cost Plus Drug Company
Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for peginterferon alfa-2a.
Browse Cost Plus medications →
GoodRx
Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.
Lookup Pegasys →
NeedyMeds
Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.
Search for peginterferon alfa-2a →
RxAssist
PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.
Search PAPs →
We deep-link because transparency helps patients. None of these partners pay RxCopays.
Conditions we've indexed resources for
Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.
Medicare Part D coverage
How Pegasys appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-08-31).
Covered by plans
55%
3,047 of 5,499 plans
Most common tier
Tier 5
On 79% of covering formularies
Prior authorization required
70%
of covering formularies
| Tier | Formularies on this tier | Share |
|---|---|---|
| Tier 1 (preferred generic) | 59 | 18% |
| Tier 2 (generic) | 2 | 1% |
| Tier 4 (non-preferred brand) | 7 | 2% |
| Tier 5 (specialty) | 259 | 79% |
| Tier 6 | 1 | 0% |
Step therapy: 0% of formularies
Quantity limits: 29% of formularies
Coverage breadth: 328 of 65 formularies
How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).
Prior authorization & coverage
| Payer | PA | Step therapy | Copay tier |
|---|---|---|---|
— Medicare Part D | Yes | — | — |
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How this page is sourced
- Drug identity verified against openFDA NDC Directory.
- Label text (when shown) originates from NLM DailyMed.
- Copay and assistance URLs verified periodically; if you hit a broken link, tell us.