Pentasa
Generic: mesalamine
- Manufacturer
- Takeda
- NDC
- 54092-189
- RxCUI
- 206791
- Route
- ORAL
- ICD-10 indication
- K51.9
Affordability Check
How much will you actually pay for Pentasa?
In 30 seconds, see every legitimate way to afford Pentasa — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.
About Pentasa
What is this medication? Pentasa is a prescription medication that contains the active ingredient mesalamine, which belongs to a class of drugs known as aminosalicylates. It is primarily used to treat and manage inflammatory bowel diseases, specifically ulcerative colitis. The medication works locally in the digestive tract to reduce inflammation, swelling, and tissue damage in the lining of the colon and rectum, which helps to alleviate symptoms such as rectal bleeding, stomach pain, and frequent diarrhea.
In addition to treating active flare-ups of mild to moderate ulcerative colitis, Pentasa is often prescribed as a maintenance therapy to help patients stay in remission. By controlling the underlying inflammation over the long term, the drug helps prevent the recurrence of symptoms. While it is most commonly associated with ulcerative colitis, some healthcare providers may also use it to manage certain cases of Crohn's disease that affect the colon. It is typically administered as extended-release capsules designed to release the medication gradually throughout the intestinal tract.
Copay & patient assistance
Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.
External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.
Compare pricing elsewhere
RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.
Cost Plus Drug Company
Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for mesalamine.
Browse Cost Plus medications →
GoodRx
Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.
Lookup Pentasa →
NeedyMeds
Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.
Search for mesalamine →
RxAssist
PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.
Search PAPs →
We deep-link because transparency helps patients. None of these partners pay RxCopays.
Conditions we've indexed resources for
Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.
Medicare Part D coverage
How Pentasa appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-08-31).
Covered by plans
21%
1,175 of 5,499 plans
Most common tier
Tier 4
On 71% of covering formularies
Prior authorization required
0%
of covering formularies
| Tier | Formularies on this tier | Share |
|---|---|---|
| Tier 1 (preferred generic) | 5 | 14% |
| Tier 2 (generic) | 2 | 6% |
| Tier 3 (preferred brand) | 3 | 9% |
| Tier 4 (non-preferred brand) | 25 | 71% |
Step therapy: 0% of formularies
Quantity limits: 71% of formularies
Coverage breadth: 35 of 65 formularies
How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).
Prior authorization & coverage
| Payer | PA | Step therapy | Copay tier |
|---|---|---|---|
— Medicare Part D | — | — | — |
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How this page is sourced
- Drug identity verified against openFDA NDC Directory.
- Label text (when shown) originates from NLM DailyMed.
- Copay and assistance URLs verified periodically; if you hit a broken link, tell us.