How much does Prilosec cost?

Pricing for Prilosec varies by insurance plan, dose, and pharmacy. Our database does not show a fixed cost because prices change faster than we can verify. For current pharmacy prices, check your insurance's formulary tier (in the prior-authorization section), use the GoodRx or Cost Plus Drugs deep links on this page, or ask your pharmacist to run a test claim. If a copay card is listed, it usually drops the out-of-pocket significantly for commercial insurance.

Does Prilosec need prior authorization?

Prilosec appears on 1 payer formulary in our database. PA requirements vary by payer — see the prior-authorization table on this page for specifics. In general, specialty and brand-name drugs are more likely to require PA than generic equivalents.

Is there a copay card or patient assistance program for Prilosec?

We haven't verified an active copay card or PAP for Prilosec in our current data. Check NeedyMeds or RxAssist for independent directories, or submit what you find via our "Report a broken link" form.

Does Prilosec have a generic version?

The generic name for Prilosec is omeprazole magnesium. Whether a generic is currently available depends on patent status — check the FDA Orange Book or ask your pharmacist. Generics are often substantially cheaper than brand-name drugs.

Prilosec

Generic: omeprazole magnesium

Verified·Apr 23, 2026

NDC: 37000-455
RxCUI: 402014
Route: ORAL
ICD-10 indication: K21.0

Affordability Check

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About Prilosec

What is this medication?

Prilosec, which is the brand name for the generic drug omeprazole, belongs to a class of medications known as proton pump inhibitors. It works by reducing the amount of acid produced in the stomach, providing relief for people suffering from frequent heartburn and acid reflux. This medication is primarily used to treat gastroesophageal reflux disease, or GERD, a condition where stomach acid flows back into the esophagus and causes irritation. It is also effective in treating erosive esophagitis, which is the physical damage to the lining of the esophagus caused by persistent acid exposure.

Beyond treating reflux symptoms, Prilosec is used to treat and prevent various types of ulcers in the stomach and small intestine. It may also be prescribed for long-term management of conditions that cause excessive stomach acid production, such as Zollinger-Ellison syndrome. In certain cases, healthcare providers use it in combination with antibiotics to eliminate H. pylori, a bacterial infection that can lead to ulcers. While it is available over the counter for short-term relief, the prescription strength is often used for more serious or chronic digestive health issues under medical supervision.

Copay & patient assistance

Patient Copay Amount: Not Publicly Available
Maximum Annual Benefit Limit: Not Publicly Available
Core Eligibility Restrictions: Eligibility for the Co-Pay Savings Program requires patients to have commercial insurance and not be enrolled in any state or federally funded programs (such as Medicare, Medicaid, or TRICARE). The AZ&Me Prescription Savings Program is available to qualifying uninsured patients and those on Medicare who meet specific criteria.
RxBIN, PCN, and Group numbers: Not Publicly Available

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for omeprazole magnesium.

Browse Cost Plus medications →

GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

Lookup Prilosec →

NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

Search for omeprazole magnesium →

RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

Search PAPs →

We deep-link because transparency helps patients. None of these partners pay RxCopays.

Prescribing information

From the FDA-approved label for Prilosec. Official source: DailyMed (NLM) · Label effective Oct 1, 2025

Indications and usage

Use treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect

Dosage and administration

Directions for adults 18 years of age and older this product is to be used once a day (every 24 hours), every day for 14 days it may take 1 to 4 days for full effect; some people get complete relief of symptoms within 24 hours 14-Day Course of Treatment swallow 1 tablet with a glass of water before eating in the morning take every day for 14 days do not take more than 1 tablet a day do not use for more than 14 days unless directed by your doctor swallow whole. Do not chew or crush tablets. Repeated 14-Day Courses (if needed) you may repeat a 14-day course every 4 months do not take for more than 14 days or more often than every 4 months unless directed by a doctor children under 18 years of age: ask a doctor. Heartburn in children may sometimes be caused by a serious condition.

Warnings

Warnings Allergy Alert: Do not use if you are allergic to omeprazole Omeprazole may cause severe skin reactions. Symptoms may include: • skin reddening • blisters • rash If an allergic reaction occurs, stop use and seek medical help right away.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Prior authorization & coverage

Payer	PA	Step therapy	Copay tier
— Medicare Part D	—	—	—

Payer

Step therapy

Copay tier

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Medicare Part D

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How this page is sourced

Drug identity verified against openFDA NDC Directory.
Label text (when shown) originates from NLM DailyMed.
Copay and assistance URLs verified periodically; if you hit a broken link, tell us.