How much does Siyntherma Plus cost?

Pricing for Siyntherma Plus varies by insurance plan, dose, and pharmacy. Our database does not show a fixed cost because prices change faster than we can verify. For current pharmacy prices, check your insurance's formulary tier (in the prior-authorization section), use the GoodRx or Cost Plus Drugs deep links on this page, or ask your pharmacist to run a test claim. If a copay card is listed, it usually drops the out-of-pocket significantly for commercial insurance.

Does Siyntherma Plus need prior authorization?

Siyntherma Plus appears on 1 payer formulary in our database. PA requirements vary by payer — see the prior-authorization table on this page for specifics. In general, specialty and brand-name drugs are more likely to require PA than generic equivalents.

Is there a copay card or patient assistance program for Siyntherma Plus?

We haven't verified an active copay card or PAP for Siyntherma Plus in our current data. Check NeedyMeds or RxAssist for independent directories, or submit what you find via our "Report a broken link" form.

What is Siyntherma Plus used to treat?

Siyntherma Plus (generic: Lidocaine) is indicated for Rosacea, Post-herpetic neuralgia. Click any condition name on this page for more detail.

Does Siyntherma Plus have a generic version?

The generic name for Siyntherma Plus is Lidocaine. Whether a generic is currently available depends on patent status — check the FDA Orange Book or ask your pharmacist. Generics are often substantially cheaper than brand-name drugs.

Siyntherma Plus

Generic: Lidocaine

Verified·Apr 23, 2026

NDC: 72835-102
RxCUI: 415976
ICD-10 indication: L71.9

Affordability Check

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About Siyntherma Plus

What is this medication? Siyntherma Plus is a prescription medication primarily used to manage chronic pain and inflammatory conditions. It is often prescribed for patients suffering from moderate to severe symptoms associated with osteoarthritis, rheumatoid arthritis, or acute musculoskeletal injuries. The Plus formulation usually indicates a combination of active ingredients designed to provide multi-layered relief by targeting both the physical sensation of pain and the underlying biological response that causes swelling and stiffness in the joints and tissues. The medication works by inhibiting the production of specific enzymes and chemicals in the body that trigger inflammatory responses and transmit pain signals to the brain. By lowering these levels, it helps to restore mobility and improve the daily quality of life for individuals dealing with persistent physical discomfort. Patients are typically instructed to take the medication exactly as directed by a healthcare professional, often with a meal to minimize the risk of gastrointestinal irritation.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for Lidocaine.

Browse Cost Plus medications →

GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

Lookup Siyntherma Plus →

NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

Search for Lidocaine →

RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

Search PAPs →

We deep-link because transparency helps patients. None of these partners pay RxCopays.

Prescribing information

From the FDA-approved label for Siyntherma Plus. Official source: DailyMed (NLM) · Label effective Dec 19, 2024

Indications and usage

For the temporary relief of pain, soreness, and burning. Helps relieve the local itching and discomfort associated with hemorrhoids. Temporarily shrinks hemorrhoidal tissue. Temporarily provides a coating for the relief of anorectal discomforts. Temporarily protects the inflamed, irritated anorectal surface to help make bowel movements less painful.

Dosage and administration

Adults: when practical, cleanse area with mild soap and warm water and rinse thoroughly. Gently dry by patting or blotting with toilet tissue or soft cloth before applying. Adults and children 12 years and older: apply externally to the affected area up to 4 times a day. Children under 12 years of age: consult a doctor.

Warnings

For external use only. Ask a doctor before use if you have: heart disease, high blood pressure, thyroid disease, diabetes, or difficulty in urination due to enlargement of the prostate gland. Ask a doctor or pharmacist before use if you are presently taking a prescription drug for high blood pressure or depression. When using this product : avoid contact with eyes, do not exceed recommended dosage unless directed by a doctor, do not put this product into rectum by using fingers or any mechanical device or applicator. Stop use and ask a doctor if : rectal bleeding occurs, condition worsens or does not improve within seven (7) days, allergic reaction occurs to ingredients in this product, symptom being treated does not subside or if redness, irritation, swelling, pain or other symptoms develop or increase, symptoms clear up and return within a few days.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

Payer	PA	Step therapy	Copay tier
— Medicare Part D	—	—	—

Payer

Step therapy

Copay tier

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Medicare Part D

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Related drugs

How this page is sourced

Drug identity verified against openFDA NDC Directory.
Label text (when shown) originates from NLM DailyMed.
Copay and assistance URLs verified periodically; if you hit a broken link, tell us.