WAINUA

What is this medication? WAINUA, which carries the generic name eplontersen, is a prescription medication used to treat adults with the polyneuropathy of hereditary transthyretin-mediated amyloidosis, or hATTR. This condition involves the buildup of abnormal protein deposits in the nerves, which can cause symptoms such as numbness, tingling, and muscle weakness in the hands and feet. By targeting the source of these proteins, the medicine helps to slow the progression of the disease and manage the neurological complications that often interfere with daily activities.

The drug functions as an antisense oligonucleotide that reduces the production of the transthyretin protein by the liver. It is administered through a monthly subcutaneous injection, often using a single-dose autoinjector that allows for convenient dosing at home. Because the medication lowers the levels of transthyretin, it can also decrease the amount of vitamin A in the blood, so patients are usually instructed to take daily vitamin A supplements while undergoing treatment. Patients should always consult with their healthcare provider to monitor their progress and manage any potential side effects.