How much does XHANCE cost?

Pricing for XHANCE varies by insurance plan, dose, and pharmacy. Our database does not show a fixed cost because prices change faster than we can verify. For current pharmacy prices, check your insurance's formulary tier (in the prior-authorization section), use the GoodRx or Cost Plus Drugs deep links on this page, or ask your pharmacist to run a test claim. If a copay card is listed, it usually drops the out-of-pocket significantly for commercial insurance.

Does XHANCE need prior authorization?

XHANCE appears on 1 payer formulary in our database. PA requirements vary by payer — see the prior-authorization table on this page for specifics. In general, specialty and brand-name drugs are more likely to require PA than generic equivalents.

Is there a copay card or patient assistance program for XHANCE?

Yes — the manufacturer copay card link is available on this page. A patient assistance program is also available for qualifying patients. Eligibility typically depends on insurance type and income. Click the CTA buttons above to apply directly through the manufacturer's portal.

What is XHANCE used to treat?

XHANCE (generic: fluticasone propionate) is indicated for Chronic Sinusitis, Nasal Congestion, Hay Fever. Click any condition name on this page for more detail.

Does XHANCE have a generic version?

The generic name for XHANCE is fluticasone propionate. Whether a generic is currently available depends on patent status — check the FDA Orange Book or ask your pharmacist. Generics are often substantially cheaper than brand-name drugs.

XHANCE

Generic: fluticasone propionate

Verified·Oct 26, 2026

Manufacturer: Optinose
NDC: 71715-003
RxCUI: 1946583
Route: NASAL
ICD-10 indication: J32.9

Affordability Check

How much will you actually pay for XHANCE?

In 30 seconds, see every legitimate way to afford XHANCE — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.

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About XHANCE

What is this medication? XHANCE is a prescription nasal spray containing fluticasone propionate, which is a type of medicine known as a corticosteroid. It features a specialized Exhalation Delivery System that sets it apart from conventional nasal sprays. To use it, a person blows into a mouthpiece while the spray is released into the nostril. This technique utilizes the air pressure from the breath to push the medication deep into the nasal cavities and sinus areas where inflammation often occurs.

The medication is primarily used to treat nasal polyps in adults and to manage the symptoms of chronic rhinosinusitis. By reducing inflammation in the nasal passages, it helps alleviate common issues like nasal congestion, facial pain, and a runny nose. Because it targets the underlying swelling associated with these conditions, it is intended for regular, daily use to achieve the best results in shrinking polyps and improving breathing.

Copay & patient assistance

Patient Copay Amount: As little as $0
Maximum Annual Benefit Limit: Not Publicly Available
Core Eligibility Restrictions: Patients must be commercially insured. Offer is not valid for patients enrolled in any government-funded prescription insurance program (e.g., Medicare, Medicaid).
RxBIN, PCN, and Group numbers: Not Publicly Available

Copay card →Patient Assistance Program →

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for fluticasone propionate.

Browse Cost Plus medications →

GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

Lookup XHANCE →

NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

Search for fluticasone propionate →

RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

Search PAPs →

We deep-link because transparency helps patients. None of these partners pay RxCopays.

Prescribing information

From the FDA-approved label for XHANCE. Official source: DailyMed (NLM) · Label effective Jul 17, 2026

Indications and usage

Uses Temporarily relieves these symptoms of hay fever or other upper respiratory allergies: nasal congestion itchy, watery eyes itchy nose runny nose sneezing

Dosage and administration

Directions read the Quick Start Guide for how to: prime the bottle use the spray clean the spray nozzle shake gently before each use use this product only once a day do not use more than directed ADULTS AND CHILDREN 12 YEARS OF AGE AND OLDER Week 1- use 2 sprays in each nostril once daily Week 2 through 6 months- use 1 or 2 sprays in each nostril once daily, as needed to treat your symptoms After 6 months of daily use – ask your doctor if you can keep using CHILDREN 4 TO 11 YEARS OF AGE the growth rate of some children may be slower while using this product. Children should use for the shortest amount of time necessary to achieve symptom relief. Talk to your child’s doctor if your child needs to use the spray for longer than two months a year. an adult should supervise use use 1 spray in each nostril once daily CHILDREN UNDER 4 YEARS OF AGE do not use

Warnings

Warnings Only for use in the nose. Do not spray into your eyes or mouth.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Medicare Part D coverage

How XHANCE appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-08-31).

Covered by plans

33%

1,791 of 5,499 plans

Most common tier

Tier 4

On 77% of covering formularies

Prior authorization required

66%

of covering formularies

Tier	Formularies on this tier	Share
Tier 1 (preferred generic)	18	17%
Tier 2 (generic)	1	1%
Tier 3 (preferred brand)	5	5%
Tier 4 (non-preferred brand)	80	77%

Step therapy: 14% of formularies

Quantity limits: 88% of formularies

Coverage breadth: 104 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

Payer	PA	Step therapy	Copay tier
— Medicare Part D	—	—	—

Payer

Step therapy

Copay tier

—

Medicare Part D

—

Related drugs

How this page is sourced

Drug identity verified against openFDA NDC Directory.
Label text (when shown) originates from NLM DailyMed.
Copay and assistance URLs verified periodically; if you hit a broken link, tell us.