How much does COLLAGENASE SANTYL cost?

Pricing for COLLAGENASE SANTYL varies by insurance plan, dose, and pharmacy. Our database does not show a fixed cost because prices change faster than we can verify. For current pharmacy prices, check your insurance's formulary tier (in the prior-authorization section), use the GoodRx or Cost Plus Drugs deep links on this page, or ask your pharmacist to run a test claim. If a copay card is listed, it usually drops the out-of-pocket significantly for commercial insurance.

Does COLLAGENASE SANTYL need prior authorization?

COLLAGENASE SANTYL appears on 1 payer formulary in our database. PA requirements vary by payer — see the prior-authorization table on this page for specifics. In general, specialty and brand-name drugs are more likely to require PA than generic equivalents.

Is there a copay card or patient assistance program for COLLAGENASE SANTYL?

Yes — the manufacturer copay card link is available on this page. A patient assistance program is also available for qualifying patients. Eligibility typically depends on insurance type and income. Click the CTA buttons above to apply directly through the manufacturer's portal.

What is COLLAGENASE SANTYL used to treat?

COLLAGENASE SANTYL (generic: COLLAGENASE SANTYL) is indicated for Pressure Ulcer. Click any condition name on this page for more detail.

COLLAGENASE SANTYL

Generic: COLLAGENASE SANTYL

Verified·Apr 23, 2026

Manufacturer: Smith and Nephew
NDC: 50484-010
RxCUI: 309509
Route: TOPICAL
ICD-10 indication: L89.909

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About COLLAGENASE SANTYL

What is this medication?

Collagenase Santyl is a prescription enzymatic debriding ointment primarily used for the treatment of chronic skin ulcers and severe burns. Its main purpose is to remove necrotic, or dead, tissue from the site of a wound, a process known as debridement. Removing this damaged material is essential because it allows the wound to begin the natural healing process and prevents the accumulation of waste that could hinder recovery.

This medication contains a specific enzyme that works by breaking down the collagen strands that hold dead tissue to the wound bed. Because the enzyme is selective, it targets the necrotic tissue while leaving healthy, viable tissue intact. It is frequently prescribed for individuals suffering from pressure sores, diabetic ulcers, or venous stasis ulcers to help maintain a clean environment for new skin to grow.

Copay & patient assistance

Patient Copay Amount: $50
Maximum Annual Benefit Limit: $1,000 per year (Up to $250 per fill for a maximum of six fills)
Core Eligibility Restrictions: Not valid for patients enrolled in government-funded healthcare programs including Medicare (including Part D and Medicare Advantage), Medicaid, TRICARE, CHAMPUS, or the Puerto Rico Government Health Insurance Plan; must be a resident of the U.S.; not valid where prohibited by law.
RxBIN, PCN, and Group numbers: Not Publicly Available

Copay card →Patient Assistance Program →

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for COLLAGENASE SANTYL.

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GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

Lookup COLLAGENASE SANTYL →

NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

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RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

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We deep-link because transparency helps patients. None of these partners pay RxCopays.

Prescribing information

From the FDA-approved label for COLLAGENASE SANTYL. Official source: DailyMed (NLM) · Label effective May 17, 2019

Indications and usage

INDICATIONS AND USAGE Collagenase Santyl ◊ Ointment is indicated for debriding chronic dermal ulcers 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 and severely burned areas. 3, 4, 5, 7, 16, 19, 20, 21

Dosage and administration

DOSAGE AND ADMINISTRATION Collagenase Santyl ◊ Ointment should be applied once daily (or more frequently if the dressing becomes soiled, as from incontinence). When clinically indicated, crosshatching thick eschar with a #10 blade allows Collagenase Santyl ◊ Ointment more surface contact with necrotic debris. It is also desirable to remove, with forceps and scissors, as much loosened detritus as can be done readily. Use Collagenase Santyl ◊ Ointment in the following manner: 1 - Prior to application the wound should be cleansed of debris and digested material by gently rubbing with a gauze pad saturated with normal saline solution, or with the desired cleansing agent compatible with Collagenase Santyl ◊ Ointment (See PRECAUTIONS ), followed by a normal saline solution rinse. 2 - Whenever infection is present, it is desirable to use an appropriate topical antibiotic powder. The antibiotic should be applied to the wound prior to the application of Collagenase Santyl ◊ Ointment. Should the infection not respond, therapy with Collagenase Santyl ◊ Ointment should be discontinued until remission of the infection. 3 - Collagenase Santyl ◊ Ointment may be applied directly to the wound or to a sterile gauze pad which is then applied to the wound and properly secured. 4 - Use of Collagenase Santyl ◊ Ointment should be terminated when debridement of necrotic tissue is complete and granulation tissue is well established.

Contraindications

CONTRAINDICATIONS Collagenase Santyl ◊ Ointment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase.

Adverse reactions

ADVERSE REACTIONS No allergic sensitivity or toxic reactions have been noted in clinical use when used as directed. However, one case of systemic manifestations of hypersensitivity to collagenase in a patient treated for more than one year with a combination of collagenase and cortisone has been reported.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Pressure Ulcer

Medicare Part D coverage

How COLLAGENASE SANTYL appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-04-30).

Covered by plans

81%

4,453 of 5,509 plans

Most common tier

Tier 4

On 58% of covering formularies

Prior authorization required

28%

of covering formularies

Tier	Formularies on this tier	Share
Tier 1 (preferred generic)	58	18%
Tier 2 (generic)	2	1%
Tier 3 (preferred brand)	74	23%
Tier 4 (non-preferred brand)	187	58%

Step therapy: 0% of formularies

Quantity limits: 88% of formularies

Coverage breadth: 321 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

Payer	PA	Step therapy	Copay tier
— Medicare Part D	—	—	—

Payer

Step therapy

Copay tier

—

Medicare Part D

—

Related drugs

SSD
Also from Smith and Nephew · Silver Sulfadiazine

How this page is sourced

Drug identity verified against openFDA NDC Directory.
Label text (when shown) originates from NLM DailyMed.
Copay and assistance URLs verified periodically; if you hit a broken link, tell us.