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Hydrocortisone Cream

Generic: Hydrocortisone

Verified·Apr 23, 2026
NDC
58228-2896
RxCUI
106258
Route
TOPICAL
ICD-10 indication
L30.9

Affordability Check

How much will you actually pay for Hydrocortisone Cream?

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About Hydrocortisone Cream

What is this medication?

Hydrocortisone cream is a topical corticosteroid used to treat a wide variety of skin conditions that cause inflammation, redness, and itching. It works by reducing the body's natural inflammatory response to irritants, allergens, or underlying medical issues. This medication is commonly prescribed to manage symptoms of skin problems such as dermatitis, eczema, and persistent rashes. It is intended for external use only and should be applied directly to the affected area as directed by a healthcare provider to ensure safety and effectiveness.

In addition to chronic conditions, hydrocortisone cream can provide temporary relief from minor skin irritations like insect bites, poison ivy, or allergic reactions to detergents and jewelry. By suppressing the local immune response, the cream helps to alleviate swelling and discomfort relatively quickly. While lower strengths of the cream are often available over the counter, higher concentrations require a prescription to treat more severe or stubborn cases of skin inflammation.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

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Prescribing information

From the FDA-approved label for Hydrocortisone Cream. Official source: DailyMed (NLM) · Label effective Dec 15, 2025

Indications and usage
Use(s) For the temporary relief of itching associated with minor skin irritations, inflammation, and rashes due to eczema, insect bites, poison ivy, poison oak, poison sumac, soaps, detergents, cosmetics, jewelry, seborrheic dermatitis, psoriasis, and external genital, feminine, and anal itching
Dosage and administration
Directions • Adults and children 2 years of age and older: Apply to affected area not more than 3 to 4 times daily. • Children under 2 years of age: Consult a doctor. • When used for anal itching, cleanse the affected area with mild soap and warm water and rinse thoroughly. Gently dry, patting or blotting with bathroom tissue or soft cloth before applying. Children under 12: Consult a doctor before using for anal itching.
Warnings
Warnings For External Use Only If pregnant or breast-feeding Ask a health professional before use Do not use • In the eyes • For diaper rash • For external genital or feminine itching if you have a vaginal discharge • More than the recommended daily dosage unless directed by a doctor • In the rectum by using fingers or any mechanical device or applicator Stop use and ask a doctor if • Condition worsens or if symptoms persist for more than 7 days or clear up and occur again within a few days (do not continue to use this or any other hydrocortisone product for longer than 7 days) • Bleeding occurs due to anal itching Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Medicare Part D coverage

How Hydrocortisone Cream appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-04-30).

Covered by plans

69%

3,777 of 5,509 plans

Most common tier

Tier 1

On 50% of covering formularies

Prior authorization required

0%

of covering formularies

TierFormularies on this tierShare
Tier 1 (preferred generic)161
50%
Tier 2 (generic)159
49%
Tier 3 (preferred brand)4
1%

Step therapy: 0% of formularies

Quantity limits: 12% of formularies

Coverage breadth: 324 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

PayerPAStep therapyCopay tier

Medicare Part D

Related drugs

How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.