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Kodatef

Generic: tafenoquine

Verified·Apr 23, 2026
NDC
71475-258
RxCUI
2054096
Route
ORAL
ICD-10 indication
Z29.8

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About Kodatef

What is this medication? Kodatef is a prescription medication that contains the active ingredient pretomanid. It belongs to a class of drugs known as nitroimidazoles and is specifically used for the treatment of adults with pulmonary tuberculosis that is either extensively drug-resistant or multidrug-resistant. Because of the complex nature of these infections, this medicine is not used alone but is administered as part of a specific combination regimen alongside bedaquiline and linezolid. The medication works by inhibiting the growth of the bacteria responsible for tuberculosis, known as Mycobacterium tuberculosis. By blocking the synthesis of cell walls and interfering with bacterial metabolism, it helps clear the infection in patients who have not responded to standard treatments or who have highly resistant strains. It is typically prescribed by specialists in infectious diseases and requires strict adherence to the dosing schedule to ensure effectiveness and prevent further antibiotic resistance.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

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Prescribing information

From the FDA-approved label for Kodatef. Official source: DailyMed (NLM) · Label effective Feb 10, 2025

Indications and usage
Malaria prophylaxis, consistent with the approved use of ARAKODA
Dosage and administration
Loading Dose: 200 mg (two of the 100 mg filmcoated tablets) once daily for three days. Maintenance Dose: 200 mg (two of the 100 mg filmcoated tablets) once weekly – start seven days after the last loading dose.
Warnings and precautions
Hemolytic Anemia G6PD Deficiency in Pregnancy and Lactation Methemoglobinemia Psychiatric Effects Hypersensitivity Reactions Delayed Adverse Reactions, Including Hemolytic Anemia, Methemoglobinemia, Psychiatric Effects, and Hypersensitivity Reactions

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

PayerPAStep therapyCopay tier

Medicare Part D

Related drugs

How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.

Rare-disease navigation (specialists, trials, patient communities)

Kodatef treats a rare condition. For in-depth disease pages on our sister site:

UniteRare.org is our sister site for rare-disease navigation — same editorial team, same accuracy standards.