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Phesgo

Generic: pertuzumab, trastuzumab, and hyaluronidase-zzxf

Data may be stale·Apr 23, 2026
Manufacturer
Genentech
NDC
50242-245
RxCUI
2382604
Route
SUBCUTANEOUS
ICD-10 indication
C50.919

Affordability Check

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About Phesgo

What is this medication?

Phesgo is a prescription medication used for the treatment of adult patients with HER2-positive breast cancer. It is used in both early-stage breast cancer, often in combination with chemotherapy, and in cases where the cancer has metastasized to other parts of the body. The medication is a fixed-dose combination containing two monoclonal antibodies, pertuzumab and trastuzumab, along with hyaluronidase-zzxf, which is an enzyme that helps the body absorb the drugs when they are injected under the skin.

This medication is administered as a subcutaneous injection, typically into the thigh, which offers a faster delivery method compared to traditional intravenous infusions of the same drugs. By binding to the HER2 receptors found on the surface of certain cancer cells, Phesgo works to inhibit cell signaling and prevent the further growth of the tumor. Patients usually receive this treatment in a clinical setting under the supervision of a healthcare professional who monitors for any potential side effects or reactions.

Copay & patient assistance

  • Patient Copay Amount: As little as $0 per treatment
  • Maximum Annual Benefit Limit: $25,000 per calendar year
  • Core Eligibility Restrictions: Patients must have commercial (private) insurance and a valid prescription for an FDA-approved indication. Patients must be residents of the United States or U.S. Territories and be 18 years of age or older. The program is not available to individuals using federal or state-funded healthcare programs, including but not limited to Medicare, Medicaid, and TRICARE. Additionally, patients cannot be receiving assistance from the Genentech Patient Foundation or any other charitable organization for the same out-of-pocket costs.
  • RxBIN, PCN, and Group numbers: Not Publicly Available

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for pertuzumab, trastuzumab, and hyaluronidase-zzxf.

Browse Cost Plus medications →

GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

Lookup Phesgo →

NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

Search for pertuzumab, trastuzumab, and hyaluronidase-zzxf →

RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

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Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

PayerPAStep therapyCopay tier

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Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.