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UPLIZNA

Generic: Inebilizumab

Verified·Oct 26, 2026
Manufacturer
Amgen
NDC
75987-150
RxCUI
2373955
Route
INTRAVENOUS
ICD-10 indication
G36.0

Affordability Check

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About UPLIZNA

What is this medication? Uplizna is a prescription medicine used to treat neuromyelitis optica spectrum disorder, which is also known as NMOSD, in adults who are anti-aquaporin-4 antibody positive. This condition is a rare autoimmune disease that attacks the central nervous system, focusing mainly on the spinal cord and the optic nerves. The primary goal of using this treatment is to lower the risk of unpredictable relapses or attacks that can lead to cumulative neurological damage and physical disability.

The treatment works as a CD19-directed cytolytic antibody that targets and removes specific B cells from the bloodstream. These B cells are a part of the immune system that contributes to the inflammation and damage seen in patients with NMOSD. It is administered as an intravenous infusion by a medical professional, beginning with two initial loading doses followed by regular maintenance treatments every six months to help keep the disease under control.

Copay & patient assistance

  • Patient Copay Amount: As little as $0 out-of-pocket for UPLIZNA and infusion costs
  • Maximum Annual Benefit Limit: Not Publicly Available
  • Core Eligibility Restrictions: Must be a resident of the United States with commercial insurance; not valid for patients whose prescriptions are paid in part or in full by any government-funded program (including Medicare, Medicare Part D, Medicaid, Medigap, VA, CHAMPUS, Department of Defense, or TRICARE); residents of Massachusetts or Rhode Island are not eligible for administration (infusion) support; must be prescribed for an FDA-approved indication.
  • RxBIN, PCN, and Group numbers: Not Publicly Available

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Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

PayerPAStep therapyCopay tier

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Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.

Rare-disease navigation (specialists, trials, patient communities)

UPLIZNA treats 2 rare conditions. For in-depth disease pages on our sister site:

UniteRare.org is our sister site for rare-disease navigation — same editorial team, same accuracy standards.