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Uracin 20%

Generic: Urea 20%

Verified·Apr 23, 2026
NDC
59088-257
RxCUI
198886
Route
TOPICAL
ICD-10 indication
L40.9

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About Uracin 20%

What is this medication? Ureacin-20 is a topical prescription medication used to treat various skin conditions that involve dry, rough, or scaly patches. The active ingredient, urea, functions as a keratolytic and emollient, meaning it helps to soften the skin while promoting the shedding of dead skin cells. It is commonly prescribed for individuals suffering from conditions such as eczema, psoriasis, and keratosis pilaris. By increasing the skin's ability to retain moisture, it helps to alleviate itching and discomfort associated with chronic dryness. In addition to treating general skin dryness, this medication is frequently utilized to soften and remove calluses or thick skin on the hands and feet. It works by breaking down the protein keratin in the outer layer of the skin, which facilitates the removal of dead tissue. Healthcare providers may also recommend it for specific nail treatments to help dissolve damaged or thickened sections of the nail. Because it is a concentrated formulation, it should be applied only to the affected areas as directed and kept away from sensitive tissues like the eyes or mucous membranes.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

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Prescribing information

From the FDA-approved label for Uracin 20%. Official source: DailyMed (NLM) · Label effective Feb 20, 2026

Indications and usage
INDICATIONS AND USAGE For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails. Soothes rough and dry skin.
Dosage and administration
DOSAGE AND ADMINISTRATION Apply Uracin 20% Cream to affected area twice per day, or as directed by a licensed healthcare practitioner. Rub in until completely absorbed. Apply to diseased or damaged nail(s) twice per day, or as directed by a licensed healthcare practitioner.
Contraindications
CONTRAINDICATIONS This product is contraindicated in persons with known or suspected hypersensitivity to any of the ingredients of the product.
Warnings
WARNINGS FOR EXTERNAL USE ONLY. NOT FOR OPHTHALMIC USE. KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. If swallowed, get medical help or contact a Poison Control Center right away. Avoid contact with eyes, lips and mucous membranes. General This product is to be used as directed by a licensed healthcare practitioner and should not be used to treat any condition other than that for which it was prescribed. If redness or irritation occurs, discontinue use and consult a licensed healthcare practitioner. Information for Patients Patients should discontinue the use of this product if the condition becomes worse or if a rash develops in the area being treated or elsewhere. Avoid contact with eyes, lips and mucous membranes. Carcinogenesis, Mutagenesis and Impairment of Fertility: Long-term animal studies for carcinogenic potential have not been performed on this product to date. Studies on reproduction and fertility also have not been performed. Pregnancy: Category C . Animal reproduction studies have not been conducted with this product. It is also not known whether this product can affect reproduction capacity or cause fetal harm when administered to a pregnant woman. This product should be used by a pregnant woman only if clearly needed or when potential benefits outweigh potential hazards to the fetus. Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this product is administered to a nursing woman.
Adverse reactions
ADVERSE REACTIONS: Transient stinging, burning, itching or irritation may occur and normally disappear upon discontinuing the use of this product.
Use in pregnancy
Pregnancy: Category C . Animal reproduction studies have not been conducted with this product. It is also not known whether this product can affect reproduction capacity or cause fetal harm when administered to a pregnant woman. This product should be used by a pregnant woman only if clearly needed or when potential benefits outweigh potential hazards to the fetus.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.