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esomeprazole

Generic: esomeprazole magnesium

Verified·Apr 23, 2026
NDC
37808-364
RxCUI
606726
Route
ORAL
ICD-10 indication
K21.9

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About esomeprazole

What is this medication?

Esomeprazole is a prescription medication classified as a proton pump inhibitor, which works by reducing the amount of acid produced in the stomach. It is primarily used to treat gastrointestinal conditions such as gastroesophageal reflux disease, also known as GERD, where stomach acid flows back into the esophagus and causes heartburn. By lowering acid levels, the medication helps alleviate painful symptoms and allows the lining of the esophagus to heal from acid damage.

In addition to treating acid reflux, esomeprazole is used to decrease the risk of stomach ulcers in patients who take nonsteroidal anti-inflammatory drugs regularly. It is also prescribed to treat conditions involving excessive stomach acid secretion, such as Zollinger-Ellison syndrome, and to help eradicate H. pylori infections when used in combination with antibiotics. This medication is available in various forms, including delayed-release capsules and oral suspensions, to help manage chronic digestive issues and prevent future complications related to excess gastric acid.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

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Prescribing information

From the FDA-approved label for esomeprazole. Official source: DailyMed (NLM) · Label effective Oct 28, 2025

Indications and usage
Use(s) treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect
Dosage and administration
Directions adults 18 years of age and older this product is to be used once a day (every 24 hours), every day for 14 days may take 1 to 4 days for full effect 14-Day Course of Treatment swallow 1 capsule with a glass of water before eating in the morning take every day for 14 days do not take more than 1 capsule a day swallow whole. Do not crush or chew capsules do not use for more than 14 days unless directed by your doctor Repeated 14-Day Courses (if needed) you may repeat a 14-day course every 4 months do not take for more than 14 days or more often than every 4 months unless directed by a doctor children under 18 years of age: ask a doctor before use. Heartburn in children may sometimes be caused by a serious condition.
Warnings
Warnings Allergy alert: Do not use if you are allergic to esomeprazole Esomeprazole may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If an allergic reaction occurs, stop use and seek medical help right away. Do not use if you have trouble or pain swallowing food, vomiting with blood, or bloody or black stools heartburn with lightheadedness, sweating or dizziness chest pain or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck or shoulders; or lightheadedness frequent chest pain. These may be signs of a serious condition. See your doctor. Ask a doctor before use if you have had heartburn over 3 months. This may be a sign of a more serious condition. frequent wheezing, particularly with heartburn unexplained weight loss nausea or vomiting stomach pain Ask a doctor or pharmacist before use if you are taking a prescription drug. Acid reducers may interact with certain prescription drugs. Stop use and ask doctor if your heartburn continues or worsens you need to take this product for more than 14 days you need to take more than 1 course of treatment every 4 months you get diarrhea you develop a rash or joint pain If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Medicare Part D coverage

How esomeprazole appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-04-30).

Covered by plans

74%

4,102 of 5,509 plans

Most common tier

Tier 2

On 39% of covering formularies

Prior authorization required

0%

of covering formularies

TierFormularies on this tierShare
Tier 1 (preferred generic)79
26%
Tier 2 (generic)121
39%
Tier 3 (preferred brand)90
29%
Tier 4 (non-preferred brand)19
6%

Step therapy: 17% of formularies

Quantity limits: 81% of formularies

Coverage breadth: 309 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

PayerPAStep therapyCopay tier

Medicare Part D

Related drugs

How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.