How much does Nystatin Cream cost?

Pricing for Nystatin Cream varies by insurance plan, dose, and pharmacy. Our database does not show a fixed cost because prices change faster than we can verify. For current pharmacy prices, check your insurance's formulary tier (in the prior-authorization section), use the GoodRx or Cost Plus Drugs deep links on this page, or ask your pharmacist to run a test claim. If a copay card is listed, it usually drops the out-of-pocket significantly for commercial insurance.

Does Nystatin Cream need prior authorization?

Nystatin Cream appears on 1 payer formulary in our database. PA requirements vary by payer — see the prior-authorization table on this page for specifics. In general, specialty and brand-name drugs are more likely to require PA than generic equivalents.

Is there a copay card or patient assistance program for Nystatin Cream?

We haven't verified an active copay card or PAP for Nystatin Cream in our current data. Check NeedyMeds or RxAssist for independent directories, or submit what you find via our "Report a broken link" form.

What is Nystatin Cream used to treat?

Nystatin Cream (generic: NYSTATIN) is indicated for Candidiasis of the Skin and Nails, Candidiasis. Click any condition name on this page for more detail.

Does Nystatin Cream have a generic version?

The generic name for Nystatin Cream is NYSTATIN. Whether a generic is currently available depends on patent status — check the FDA Orange Book or ask your pharmacist. Generics are often substantially cheaper than brand-name drugs.

Nystatin Cream

Generic: NYSTATIN

Verified·Apr 23, 2026

NDC: 0316-0221
RxCUI: 884308
Route: TOPICAL
ICD-10 indication: B37.2

Affordability Check

How much will you actually pay for Nystatin Cream?

In 30 seconds, see every legitimate way to afford Nystatin Cream — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.

Check my options →

About Nystatin Cream

What is this medication? Nystatin cream is a topical antifungal medication primarily used to treat skin infections caused by yeast or fungi. It is specifically effective against Candida species, which can cause irritation, itching, and redness in various parts of the body. Doctors often prescribe this cream for conditions such as cutaneous candidiasis, which frequently appears in skin folds, the groin area, or under the breasts where moisture tends to accumulate. The medication works by disrupting the cell membranes of the fungi, effectively stopping their growth and allowing the skin to heal over time. It is typically applied to the affected area several times a day as directed by a healthcare professional until the infection is completely cleared. While it is highly effective for yeast infections of the skin, it is not used to treat infections caused by bacteria or viruses, and it should only be used for the specific condition for which it was prescribed.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for NYSTATIN.

Browse Cost Plus medications →

GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

Lookup Nystatin Cream →

NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

Search for NYSTATIN →

RxAssist

PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.

Search PAPs →

We deep-link because transparency helps patients. None of these partners pay RxCopays.

Prescribing information

From the FDA-approved label for Nystatin Cream. Official source: DailyMed (NLM) · Label effective Jan 12, 2026

Indications and usage

INDICATIONS AND USAGE Nystatin cream is indicated in the treatment of cutaneous or mucocutaneous mycotic infections caused by Candida albicans and other susceptible Candida species. This cream is not indicated for systemic, oral, intravaginal or ophthalmic use.

Dosage and administration

DOSAGE AND ADMINISTRATION Adults and Pediatric Patients (Neonates and Older) Apply liberally to affected areas twice daily or as indicated until healing is complete.

Contraindications

CONTRAINDICATIONS Nystatin cream is contraindicated in patients with a history of hypersensitivity to any of its components.

Adverse reactions

ADVERSE REACTIONS The frequency of adverse events reported in patients using nystatin cream is less than 0.1%. The more common events that were reported include allergic reactions, burning, itching, rash, eczema, and pain on application. (See PRECAUTIONS: General .) To report SUSPECTED ADVERSE REACTIONS, contact Crown Laboratories, Inc. at 1-423-926-4413 or FDA at 1-800-FDA-1088 or https://www.fda.gov/Safety/MedWatch/

Use in pregnancy

Pregnancy Teratogenic Effects Category C Animal reproduction studies have not been conducted with any nystatin cream. It also is not known whether this cream can cause fetal harm when used by a pregnant woman or can affect reproductive capacity. Nystatin cream should be prescribed for a pregnant woman only if the potential benefit to the mother outweighs the potential risk to the fetus.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Medicare Part D coverage

How Nystatin Cream appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-04-30).

Covered by plans

71%

3,913 of 5,509 plans

Most common tier

Tier 2

On 66% of covering formularies

Prior authorization required

of covering formularies

Tier	Formularies on this tier	Share
Tier 1 (preferred generic)	104	32%
Tier 2 (generic)	218	66%
Tier 3 (preferred brand)	3	1%
Tier 4 (non-preferred brand)	4	1%

Step therapy: 0% of formularies

Quantity limits: 60% of formularies

Coverage breadth: 329 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

Payer	PA	Step therapy	Copay tier
— Medicare Part D	—	—	—

Payer

Step therapy

Copay tier

—

Medicare Part D

—

Related drugs

How this page is sourced

Drug identity verified against openFDA NDC Directory.
Label text (when shown) originates from NLM DailyMed.
Copay and assistance URLs verified periodically; if you hit a broken link, tell us.