SAPHNELO
Generic: Anifrolumab-fnia
- NDC
- 0310-3040
- RxCUI
- 2565280
- Route
- INTRAVENOUS
- ICD-10 indication
- M32.10
Affordability Check
How much will you actually pay for SAPHNELO?
In 30 seconds, see every legitimate way to afford SAPHNELO — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.
About SAPHNELO
What is this medication? Saphnelo is a prescription medicine used to treat adults with moderate to severe systemic lupus erythematosus, which is commonly referred to as SLE or lupus. It is typically prescribed to be used alongside other standard lupus medications to help manage the symptoms of the disease. This medication works as a type I interferon receptor antagonist, meaning it targets and blocks the action of certain proteins in the immune system that contribute to the inflammation and organ damage associated with lupus.
The medication is administered by a healthcare professional as an intravenous infusion, typically given once every four weeks. It is important to note that Saphnelo has not been studied in and is not recommended for patients with severe active lupus nephritis or severe active central nervous system lupus. Patients should consult with their healthcare provider to discuss potential side effects and to ensure this treatment is appropriate for their specific medical history and current health needs.
Copay & patient assistance
- Patient Copay Amount: As little as $0
- Maximum Annual Benefit Limit: Not Publicly Available
- Core Eligibility Restrictions: Patients must have commercial or private insurance; intended for US consumers; patient must be 18 years of age or older to participate in the support program.
- RxBIN, PCN, and Group numbers: Not Publicly Available
External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.
Compare pricing elsewhere
RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.
Cost Plus Drug Company
Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for Anifrolumab-fnia.
Browse Cost Plus medications →
GoodRx
Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.
Lookup SAPHNELO →
NeedyMeds
Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.
Search for Anifrolumab-fnia →
RxAssist
PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.
Search PAPs →
We deep-link because transparency helps patients. None of these partners pay RxCopays.
Conditions we've indexed resources for
Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.
Medicare Part D coverage
How SAPHNELO appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-08-31).
Covered by plans
1%
52 of 5,499 plans
Most common tier
Tier 5
On 75% of covering formularies
Prior authorization required
100%
of covering formularies
| Tier | Formularies on this tier | Share |
|---|---|---|
| Tier 4 (non-preferred brand) | 1 | 25% |
| Tier 5 (specialty) | 3 | 75% |
Step therapy: 0% of formularies
Quantity limits: 50% of formularies
Coverage breadth: 4 of 65 formularies
How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).
Prior authorization & coverage
| Payer | PA | Step therapy | Copay tier |
|---|---|---|---|
— Medicare Part D | — | — | — |
Related drugs
BENLYSTA
Treats same condition · belimumab
SOVUNA
Treats same condition · Hydroxychloroquine Sulfate
Dexamethasone 1.5 mg
Treats same condition · Dexamethasone 1.5 mg
Prednisone
Treats same condition · prednisone
Hydroxychloroquine
Treats same condition · Hydroxychloroquine Sulfate
HYDROXYCHLOROQUINE SULFATE
Treats same condition · Hydroxychloroquine Sulfate
Acthar
Treats same condition · Repository Corticotropin
LUPKYNIS
Treats same condition · Voclosporin
Gazyva
Treats same condition · obinutuzumab
Dexamethasone Intensol, Dexamethasone
Treats same condition
How this page is sourced
- Drug identity verified against openFDA NDC Directory.
- Label text (when shown) originates from NLM DailyMed.
- Copay and assistance URLs verified periodically; if you hit a broken link, tell us.
Rare-disease navigation (specialists, trials, patient communities)
SAPHNELO treats a rare condition. For in-depth disease pages on our sister site:
UniteRare.org is our sister site for rare-disease navigation — same editorial team, same accuracy standards.