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Selenium Sulfide

Generic: SELENIUM SULFIDE

Verified·Apr 23, 2026
NDC
16477-422
RxCUI
204642
Route
TOPICAL
ICD-10 indication
L21.0

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About Selenium Sulfide

What is this medication? Selenium sulfide is a prescription-strength topical medication categorized as an antifungal and anti-seborrheic agent. It is primarily used to treat scalp conditions such as dandruff and seborrheic dermatitis, which cause itching, redness, and flaking of the skin. It is also an effective treatment for tinea versicolor, a common fungal infection that results in small, discolored patches of skin on the trunk, arms, or neck. This medication works by slowing the growth of the yeast that triggers these skin issues and by reducing the excessive turnover of skin cells. When used as a shampoo or lotion, it helps to relieve irritation and restore the natural balance of the skin or scalp. Patients are usually instructed to apply the product to the affected area, leave it on for several minutes, and then rinse it off thoroughly to achieve the best results.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

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Prescribing information

From the FDA-approved label for Selenium Sulfide. Official source: DailyMed (NLM) · Label effective Nov 6, 2025

Indications and usage
INDICATIONS & USAGE: A liquid antiseborrheic, antifungal preparation for the treatment of seborrheic dermatitis of the scalp, dandruff and tinea versicolor. Urea hydrates and is useful for conditions such as dry scalp.
Dosage and administration
DOSAGE AND ADMINISTRATION: SHAKE WELL BEFORE USING For seborrheic dermatitis and dandruff: Generally 2 applications each week for 2 weeks will control symptoms. Subsequently, shampoo may be used less frequently – weekly, every 2 weeks, every 3 to 4 weeks or as directed by a physician. Should not be applied more frequently than necessary to maintain control. For tinea versicolor: Wet skin and apply to affected areas. Massage gently into skin working to a full lather. Allow product to remain on skin for 10 minutes, then rinse thoroughly. Repeat procedure once a day for seven days or as directed by a physician.
Contraindications
CONTRAINDICATIONS: Contraindicated in persons with known or suspected hypersensitivity to any of the listed ingredients.
Warnings
WARNINGS: For external use only. Not for ophthalmic use. DO NOT USE ON BROKEN SKIN OR INFLAMED AREAS. If allergic reaction occurs, discontinue use. Avoid contact with eyes, genital areas and skin folds, as irritation and burning may result. If accidental contact occurs, rinse thoroughly with water. KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.
Adverse reactions
ADVERSE REACTIONS: In decreasing order of severity: skin irritation; occasional reports of increase in normal hair loss; discoloration of hair (can be avoided or minimized by thorough rinsing of hair after treatment). As with other shampoos, oiliness or dryness of hair and scalp may occur.
Use in pregnancy
USE IN PREGNANCY: CATEGORY C Animal reproduction studies have not been conducted with this medication. It is also not known whether this product can cause fetal harm when applied to the body surfaces of a pregnant woman or can affect reproduction capacity. Under ordinary circumstances, selenium sulfide 2.25% shampoo should not be used by pregnant women.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Medicare Part D coverage

How Selenium Sulfide appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-04-30).

Covered by plans

71%

3,893 of 5,509 plans

Most common tier

Tier 2

On 68% of covering formularies

Prior authorization required

0%

of covering formularies

TierFormularies on this tierShare
Tier 1 (preferred generic)99
30%
Tier 2 (generic)223
68%
Tier 3 (preferred brand)2
1%
Tier 4 (non-preferred brand)3
1%

Step therapy: 0% of formularies

Quantity limits: 11% of formularies

Coverage breadth: 327 of 65 formularies

How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).

Prior authorization & coverage

PayerPAStep therapyCopay tier

Medicare Part D

Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.