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Urea 40%

Generic: Urea

Unverified·never
RxCUI
198342
Route
TOPICAL
ICD-10 indication
L85.9

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About Urea 40%

What is this medication? Urea 40% is a high-concentration topical treatment classified as a keratolytic agent. It is primarily used to treat various skin conditions characterized by dry, rough, or thickened skin, such as eczema, psoriasis, corns, and calluses. By increasing the moisture content in the skin, this medication helps to soften and dissolve the keratin that holds dead skin cells together, allowing them to shed more easily. This process helps to smooth the skin surface and reduce the discomfort associated with hyperkeratotic conditions. In addition to treating skin issues, Urea 40% is frequently prescribed for the management of damaged or thickened nails caused by fungal infections or physical trauma. When applied to the nails, the medication helps to soften the nail plate, making it easier to trim or even promoting the painless removal of a diseased nail without surgery. It is important to apply this medication only to the affected areas as directed by a healthcare professional, as its potent exfoliating properties can irritate healthy skin.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for Urea.

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GoodRx

Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.

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NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

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RxAssist

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Prescribing information

From the FDA-approved label for Urea 40%. Official source: DailyMed (NLM) · Label effective Jan 15, 2026

Indications and usage
Indications and Usage For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails.
Dosage and administration
Dosage and Administration Apply Urea 40% to affected skin twice per day, or as directed by your physician. Rub in until completely absorbed. Apply to diseased or damaged nail(s) twice per day, or as directed by a physician.
Contraindications
Contraindications Known hypersensitivity to any of the listed ingredients.
Warnings
Warnings For topical use only. Avoid contact with eyes, lips or mucous membranes.
Adverse reactions
Adverse Reactions Transient stinging, burning, itching or irritation may occur and normally disappear upon discontinuing the use of this product. To report SUSPECTED ADVERSE REACTIONS, contact Method Pharmaceuticals, LLC at 1-877-250-3427; or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch .

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

PayerPAStep therapyCopay tier

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Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.