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UREA

Generic: Urea

Verified·Apr 23, 2026
NDC
44523-617
Route
TOPICAL
ICD-10 indication
L85.8

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About UREA

What is this medication? Urea is a topical prescription medication used to treat various skin conditions characterized by dry, rough, or thickened skin. It belongs to a class of drugs known as keratolytics, which work by softening and breaking down the outer layer of the skin. This medication is commonly prescribed for conditions such as eczema, psoriasis, corns, calluses, and some nail problems. By increasing the moisture content of the skin, urea helps to dissolve the substance that holds skin cells together, allowing dead skin to shed more easily.

In addition to treating general dryness, urea is often used to promote the removal of damaged or infected nails without the need for surgery. When applied to the skin or nails, it helps to rehydrate the area and improve overall texture. Depending on the concentration, it can serve as a mild moisturizer or a potent exfoliating agent. Patients should apply this medication as directed by a healthcare professional, typically after bathing while the skin is still damp, to achieve the best results in smoothing and softening the affected areas.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

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Prescribing information

From the FDA-approved label for UREA. Official source: DailyMed (NLM) · Label effective Dec 17, 2025

Indications and usage
INDICATIONS: For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails.
Dosage and administration
DOSAGE AND ADMINISTRATION: Apply to affected area(s) twice per day or as directed by a physician. Rub in until completely absorbed. Apply to diseased or damaged nail(s) twice per day, or as directed by a physician.
Contraindications
CONTRAINDICATIONS: This product is contraindicated in persons with known or suspected hypersensitivity to any of the ingredients of the product.
Warnings
WARNING: KEEP OUT OF REACH OF CHILDREN.
Adverse reactions
ADVERSE REACTIONS: Transient stinging, burning, itching or irritation may occur and normally disappear upon discontinuing the use of this product.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

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Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.