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Urea 41%

Generic: Urea

Verified·Apr 23, 2026
NDC
85477-306
RxCUI
1436933
Route
TOPICAL
ICD-10 indication
L85.9

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About Urea 41%

What is this medication? Urea 41% is a high-potency topical treatment used to manage skin conditions that cause excessive thickness, dryness, or scaling. Doctors commonly prescribe it for hyperkeratotic conditions like psoriasis, ichthyosis, and chronic dermatitis. It is also an effective solution for treating rough calluses and corns, or for softening and removing diseased or damaged nails without the need for surgery. As a keratolytic agent, urea works by breaking down the protein keratin and the intercellular matrix that holds skin cells together. This process helps to dissolve the hardened outer layer of the skin, allowing dead tissue to shed more easily. By drawing moisture into the skin as it softens these areas, the medication helps restore a smoother texture and provides relief from discomfort caused by thick or crusty skin patches.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

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Prescribing information

From the FDA-approved label for Urea 41%. Official source: DailyMed (NLM) · Label effective Mar 6, 2026

Indications and usage
INDICATIONS AND USAGE Urea 41% Cream is indicated for debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris, or eschar. It is also indicated for the treatment of hyperkeratotic conditions such as: dry, rough skin dermatitis psoriasis xerosis ichthyosis eczema keratosis pilaris keratosis palmaris keratoderma corns and calluses damaged, ingrown, or devitalized nails
Dosage and administration
DOSAGE AND ADMINISTRATION Apply Urea 41% Cream to affected area(s) twice daily or as directed by a physician. Rub into the skin until completely absorbed. For nail conditions, apply to diseased or damaged nails twice daily or as directed by a physician.
Warnings
WARNINGS For external use only. Avoid contact with eyes, lips, or mucous membranes. Discontinue use and consult a physician if redness, irritation, or sensitivity occurs. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center immediately.

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

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Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.