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Urea Cream 40%

Generic: Urea

Unverified·never
RxCUI
198342
Route
TOPICAL
ICD-10 indication
L40.9

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About Urea Cream 40%

What is this medication? Urea cream 40% is a high-potency keratolytic medication designed to treat various skin conditions involving dry, rough, or thickened tissue. It functions by increasing the skin's moisture content and dissolving the protein matrix that holds dead skin cells together. This action helps to soften and shed excess skin, making it an effective treatment for hyperkeratotic conditions like psoriasis, eczema, calluses, and corns. By promoting the removal of dead tissue, it allows for better hydration and helps restore the skin's normal texture.

This medication is also commonly used to treat damaged, thickened, or ingrown nails caused by fungal infections or injury. The high concentration of urea softens the nail plate, facilitating the non-surgical removal of diseased nail tissue. It is usually applied directly to the affected skin or nail and may be covered with an occlusive dressing to enhance its effectiveness. Because it is a strong formulation, it should be used exactly as directed by a healthcare professional to avoid irritating healthy surrounding skin.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

Compare pricing elsewhere

RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.

Cost Plus Drug Company

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GoodRx

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NeedyMeds

Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.

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RxAssist

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Prescribing information

From the FDA-approved label for Urea Cream 40%. Official source: DailyMed (NLM) · Label effective Jan 15, 2026

Indications and usage
Indications and Usage For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails.
Dosage and administration
Dosage and Administration Apply Urea 40% to affected skin twice per day, or as directed by your physician. Rub in until completely absorbed. Apply to diseased or damaged nail(s) twice per day, or as directed by a physician.
Contraindications
Contraindications Known hypersensitivity to any of the listed ingredients.
Warnings
Warnings For topical use only. Avoid contact with eyes, lips or mucous membranes.
Adverse reactions
Adverse Reactions Transient stinging, burning, itching or irritation may occur and normally disappear upon discontinuing the use of this product. To report SUSPECTED ADVERSE REACTIONS, contact Method Pharmaceuticals, LLC at 1-877-250-3427; or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch .

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

PayerPAStep therapyCopay tier

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Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.