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Urea Cream 40 Percent

Generic: Urea

Verified·Apr 23, 2026
Manufacturer
Stratus Pharmaceuticals Inc
NDC
71335-2868
RxCUI
198342
Route
TOPICAL
ICD-10 indication
L85.9

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About Urea Cream 40 Percent

What is this medication? Urea Cream 40 Percent is a high-potency prescription topical treatment classified as a keratolytic agent. It is primarily used to treat various skin conditions characterized by dry, rough, or thickened skin, such as psoriasis, eczema, corns, calluses, and ichthyosis. By increasing the moisture levels in the skin, the medication helps to dissolve the intercellular matrix of the outer skin layer, making it easier for dead skin cells to shed and for the underlying tissue to soften. In addition to its use on the skin, this medication is frequently prescribed to treat damaged, indrawn, or devitalized nails. When applied to the nail bed, it helps soften and gradually dissolve the nail plate, which can assist in the removal of infected or thickened nails without the need for invasive surgical procedures. Because it is a strong formulation, it should be applied specifically to the affected areas as directed by a healthcare provider to avoid irritating the surrounding healthy skin.

Copay & patient assistance

Detailed copay and financial assistance information is not publicly available for this medication at this time. Please consult your pharmacist or the manufacturer's official patient support program for more details.

External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.

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Cost Plus Drug Company

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GoodRx

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NeedyMeds

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Prescribing information

From the FDA-approved label for Urea Cream 40 Percent. Official source: DailyMed (NLM) · Label effective Nov 12, 2025

Indications and usage
Indications and Usage For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails.
Dosage and administration
Dosage and Administration Apply Urea 40% to affected skin twice per day, or as directed by your physician. Rub in until completely absorbed. Apply to diseased or damaged nail(s) twice per day, or as directed by a physician.
Contraindications
Contraindications Known hypersensitivity to any of the listed ingredients.
Warnings
Warnings For topical use only. Avoid contact with eyes, lips or mucous membranes.
Adverse reactions
Adverse Reactions Transient stinging, burning, itching or irritation may occur and normally disappear upon discontinuing the use of this product. To report SUSPECTED ADVERSE REACTIONS, contact Method Pharmaceuticals, LLC at 1-877-250-3427; or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch .

Label text is reproduced as-is from the FDA-approved label. We do not paraphrase, summarize, or omit. Content above is for informational purposes only and is not medical advice. Always consult your prescribing clinician or pharmacist before making decisions about your medication.

Conditions we've indexed resources for

Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.

Prior authorization & coverage

PayerPAStep therapyCopay tier

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Medicare Part D

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How this page is sourced

  • Drug identity verified against openFDA NDC Directory.
  • Label text (when shown) originates from NLM DailyMed.
  • Copay and assistance URLs verified periodically; if you hit a broken link, tell us.