TUKYSA
Generic: tucatinib
- NDC
- 51144-001
- RxCUI
- 2361290
- Route
- ORAL
- ICD-10 indication
- C50.919
Affordability Check
How much will you actually pay for TUKYSA?
In 30 seconds, see every legitimate way to afford TUKYSA — Medicare copay, manufacturer copay card, Patient Assistance Program, grants, or cash.
About TUKYSA
What is this medication? TUKYSA is a prescription medicine used to treat adults with HER2-positive breast cancer that is advanced or has spread to other parts of the body, including the brain. It is typically prescribed for patients whose cancer cannot be removed by surgery and who have already received one or more other anti-HER2-based treatments. This medication is taken in combination with two other drugs, trastuzumab and capecitabine, to help manage the disease.
This drug is also used to treat adults with a specific type of HER2-positive colorectal cancer that has spread or is unresectable. It is intended for patients with RAS wild-type tumors that have progressed after treatment with certain types of chemotherapy. When used for colorectal cancer, TUKYSA is administered in combination with trastuzumab to block the signals that encourage cancer cells to grow and divide.
Copay & patient assistance
- Patient Copay Amount: Not Publicly Available
- Maximum Annual Benefit Limit: Not Publicly Available
- Core Eligibility Restrictions: Residents of the United States only; services only available for certain Pfizer Oncology medications
- RxBIN, PCN, and Group numbers: Not Publicly Available
External links go directly to the manufacturer's portal. RxCopays does not receive compensation for referrals.
Compare pricing elsewhere
RxCopays doesn't sell drugs or take referral fees. Here are the transparent-pricing directories we recommend checking alongside your insurance formulary.
Cost Plus Drug Company
Mark Cuban's transparent-pricing pharmacy — manufacturer cost + 15% markup + $5 dispensing fee. No insurance needed. Search alphabetically for tucatinib.
Browse Cost Plus medications →
GoodRx
Compare local pharmacy prices with GoodRx coupons. Use the price with your insurance or without — whichever is cheaper.
Lookup TUKYSA →
NeedyMeds
Independent nonprofit directory of patient assistance programs, copay cards, and charity co-pay foundations.
Search for tucatinib →
RxAssist
PAP directory maintained by Volunteers in Health Care at Brown University. Free, no ads.
Search PAPs →
We deep-link because transparency helps patients. None of these partners pay RxCopays.
Conditions we've indexed resources for
Click a condition to see copay cards, grants, and PA rules specific to it. For the full list of FDA-approved indications, see Prescribing information above.
Medicare Part D coverage
How TUKYSA appears across Medicare Part D plan formularies nationally. Source: CMS monthly Prescription Drug Plan file (2026-08-31).
Covered by plans
51%
2,779 of 5,499 plans
Most common tier
Tier 5
On 79% of covering formularies
Prior authorization required
99%
of covering formularies
| Tier | Formularies on this tier | Share |
|---|---|---|
| Tier 1 (preferred generic) | 59 | 18% |
| Tier 2 (generic) | 2 | 1% |
| Tier 4 (non-preferred brand) | 7 | 2% |
| Tier 5 (specialty) | 259 | 79% |
| Tier 6 | 1 | 0% |
Step therapy: 0% of formularies
Quantity limits: 88% of formularies
Coverage breadth: 328 of 65 formularies
How to read this:plans on the same formulary share tier + PA rules. Your specific plan's copay depends on (a) the tier above, (b) your plan's cost-share for that tier, (c) whether you're in the initial coverage phase or past the 2026 $2,000 out-of-pocket cap. For your exact plan, check its Summary of Benefits or log in to your Medicare.gov account. Copay cards don't apply to Medicare (federal law).
Prior authorization & coverage
| Payer | PA | Step therapy | Copay tier |
|---|---|---|---|
— Medicare Part D | — | — | — |
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How this page is sourced
- Drug identity verified against openFDA NDC Directory.
- Label text (when shown) originates from NLM DailyMed.
- Copay and assistance URLs verified periodically; if you hit a broken link, tell us.